[Churg-Strauss综合征伴蛛网膜下腔出血左膈神经麻痹1例]。

Kyoko Shimizu, Hiromi Ohoba, Hiroyuki Shimada, Yukihisa Inoue, Yasuto Jinn, Nobuyuki Yoshimura
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摘要

一位60岁的女性在2000年被诊断为Churg-Strauss综合征(CSS),原因是外周血嗜酸性粒细胞增多、嗜酸性粒细胞肺炎、哮喘、多关节疼痛和肢体麻木。经强的松龙(PSL)治疗,上述症状有所改善,但PSL逐渐减少后又复发。2009年9月,在PSL逐渐减少至5mg/天7天后,患者发生蛛网膜下腔出血并入院。MRA和脑血管造影未见动脉瘤;出血的来源无法确定,但她的症状表明是良性的。入院后27天胸片示左侧膈肌抬高,经膈神经刺激试验诊断为左侧膈神经麻痹。入院期间外周血嗜酸性粒细胞增多逐渐进展,虽然蛛网膜下腔出血和膈神经麻痹与CSS相关的情况并不多见,但我们认为这些均为与CSS相关的血管炎症状。
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[A case of Churg-Strauss syndrome with subarachnoid hemorrhage and left phrenic nerve paralysis].

A 60-year-old woman was given a diagnosis of Churg-Strauss syndrome (CSS) in 2000 because of peripheral blood eosinophilia, eosinophilic pneumonia, asthma, polyarticular pain, and limb numbness. She was treated with prednisolone (PSL), and the above symptoms improved but then relapsed on tapering of PSL. In September 2009, after 7 days of tapering of PSL to 5mg/day, the patient developed a subarachnoid hemorrhage and was admitted. MRA and cerebral angiography revealed no aneurysm; the source of bleeding could not be determined, but her symptoms indicated a benign course. A chest X-ray 27 days after admission showed left diaphragmatic elevation, and left phrenic nerve paralysis was diagnosed by a phrenic nerve stimulation test. Peripheral blood eosinophilia had progressed gradually during the admission period, and although it is rare for subarachnoid hemorrhage and phrenic nerve paralysis to be associated with CSS, we regarded these as vasculitis symptoms related to CSS.

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