运动中的神经元:皮层中间神经元的迁移和分层。

Q1 Medicine Neurosignals Pub Date : 2012-01-01 Epub Date: 2012-05-04 DOI:10.1159/000334489
Clare Faux, Sonja Rakic, William Andrews, Joanne M Britto
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引用次数: 67

摘要

gaba能中间神经元对皮层活动的调节是正常脑功能所必需的,并且是通过神经元群的巨大异质性来实现的。皮层中间神经元在腹侧端脑中有一个共同的起源,但在成熟过程中产生了不同的亚型,形成了在成人大脑中观察到的典型层流排列。向皮质板的长距离切向和短距离径向迁移是由内在和外在信号机制共同调控的,对这些发育事件的理解已经取得了很大进展。在这篇综述中,我们将总结关于亚型规范的分子控制的最新发现,并提供影响神经元间迁移和层压的迁移线索的详细说明。此外,功能失调的gaba能系统与许多神经和精神疾病有关,其中一些可能与中间神经元产生和迁移的改变有关。我们将讨论在人类和非人类灵长类动物中发现的中间神经元祖细胞的其他来源的概念,并说明早期发育事件的破坏如何引发gaba能功能的丧失。
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Neurons on the move: migration and lamination of cortical interneurons.

The modulation of cortical activity by GABAergic interneurons is required for normal brain function and is achieved through the immense level of heterogeneity within this neuronal population. Cortical interneurons share a common origin in the ventral telencephalon, yet during the maturation process diverse subtypes are generated that form the characteristic laminar arrangement observed in the adult brain. The long distance tangential and short-range radial migration into the cortical plate is regulated by a combination of intrinsic and extrinsic signalling mechanisms, and a great deal of progress has been made to understand these developmental events. In this review, we will summarize current findings regarding the molecular control of subtype specification and provide a detailed account of the migratory cues influencing interneuron migration and lamination. Furthermore, a dysfunctional GABAergic system is associated with a number of neurological and psychiatric conditions, and some of these may have a developmental aetiology with alterations in interneuron generation and migration. We will discuss the notion of additional sources of interneuron progenitors found in human and non-human primates and illustrate how the disruption of early developmental events can instigate a loss in GABAergic function.

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来源期刊
Neurosignals
Neurosignals 医学-神经科学
CiteScore
3.40
自引率
0.00%
发文量
3
审稿时长
>12 weeks
期刊介绍: Neurosignals is an international journal dedicated to publishing original articles and reviews in the field of neuronal communication. Novel findings related to signaling molecules, channels and transporters, pathways and networks that are associated with development and function of the nervous system are welcome. The scope of the journal includes genetics, molecular biology, bioinformatics, (patho)physiology, (patho)biochemistry, pharmacology & toxicology, imaging and clinical neurology & psychiatry. Reported observations should significantly advance our understanding of neuronal signaling in health & disease and be presented in a format applicable to an interdisciplinary readership.
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