壳聚糖基灌胃给药头孢呋辛酯:黏附方法的发展和体外评价。

Mitesh Nagar, Adhikrao V Yadav
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引用次数: 4

摘要

为了降低头孢呋辛酯的给药频率、提高其生物利用度和有效的给药体系,研制了壳聚糖基头孢呋辛酯灌胃缓释微球制剂。以三聚磷酸钠为聚阴离子,通过壳聚糖的离子化胶凝法制备了该给药体系,并通过箱形实验设计对其进行了优化。采用响应面法评价制备的黏附微珠的各种体外特性。对多个自变量进行优化,得到感兴趣的响应,从而得到头孢呋辛酯在胃环境中的缓释曲线。
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Chitosan-based intragastric delivery of cefuroxime axetil: development and in-vitro evaluation of mucoadhesive approach.

To have advantages of reduced dosing frequency, improved bioavailability and effective delivery system of Cefuroxime Axetil, a Chitosan based intragastric sustained release microbead formulation of Cefuroxime Axetil was developed. The drug delivery system was prepared by ionotropic gelation of Chitosan in presence of sodium tripolyphosphate as polyanion and optimized by box-behnken experimental design. Response surface methodology was applied to evaluate various vitro characteristics of prepared mucoadhesive microbeads. Multiple independent variables were optimized to achieve responses of interest, thereby to get the desired sustained release profile of Cefuroxime Axetil in gastric environment.

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