代谢综合征、氧化应激、环境和心血管疾病:伟大的探索。

Experimental Diabetes Research Pub Date : 2012-01-01 Epub Date: 2012-07-09 DOI:10.1155/2012/271028
Rebecca Hutcheson, Petra Rocic
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引用次数: 176

摘要

代谢综合征影响了30%的美国人口,并且患病率越来越高。在本文中,我们探讨代谢综合征与心血管疾病,特别是冠状动脉疾病(CAD)的发病率和严重程度之间的关系。此外,我们研究了代谢综合征对冠状动脉血运重建治疗结果的影响,包括冠状动脉搭桥、PTCA和冠状动脉侧枝发育。我们还研究了代谢综合征及其个体成分病理和氧化应激之间的关系。此外,我们还探讨了氧化应激的主要外部来源,香烟烟雾和空气污染与代谢综合征之间的相互作用以及这种相互作用对CAD的影响。我们讨论了在大型临床试验中抗氧化剂对心血管结果明显缺乏积极作用,并强调了这些试验的一些局限性。最后,我们提供了成功使用抗氧化药物的证据,包括二甲双胍、他汀类药物、血管紧张素II型受体阻滞剂(ARBs)和血管紧张素II转换酶(ACE)抑制剂,用于预防和治疗代谢综合征的心血管并发症。
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The metabolic syndrome, oxidative stress, environment, and cardiovascular disease: the great exploration.

The metabolic syndrome affects 30% of the US population with increasing prevalence. In this paper, we explore the relationship between the metabolic syndrome and the incidence and severity of cardiovascular disease in general and coronary artery disease (CAD) in particular. Furthermore, we look at the impact of metabolic syndrome on outcomes of coronary revascularization therapies including CABG, PTCA, and coronary collateral development. We also examine the association between the metabolic syndrome and its individual component pathologies and oxidative stress. Related, we explore the interaction between the main external sources of oxidative stress, cigarette smoke and air pollution, and metabolic syndrome and the effect of this interaction on CAD. We discuss the apparent lack of positive effect of antioxidants on cardiovascular outcomes in large clinical trials with emphasis on some of the limitations of these trials. Finally, we present evidence for successful use of antioxidant properties of pharmacological agents, including metformin, statins, angiotensin II type I receptor blockers (ARBs), and angiotensin II converting enzyme (ACE) inhibitors, for prevention and treatment of the cardiovascular complications of the metabolic syndrome.

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来源期刊
Experimental Diabetes Research
Experimental Diabetes Research 医学-内分泌学与代谢
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审稿时长
3-8 weeks
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