脂质分离技术:德国现状。

Peter Grützmacher, Claudius Kleinert
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引用次数: 8

摘要

对于长期脂质分离治疗,已经开发了几种不同的技术系统,可以有效降低LDL胆固醇和其他致动脉粥样硬化脂蛋白,如Lp(a),具有足够的选择性和良好的临床耐受性。适用的技术包括聚丙烯酰胺和葡聚糖硫酸盐纤维素全血吸附,而初级血浆分离用于级联过滤、肝素诱导沉淀、免疫吸附、硅酸盐凝胶吸附和葡聚糖硫酸盐纤维素(两种技术)。介绍了其技术特点。只有医务人员的强化培训和经验才能保证所有系统的可靠治疗安全,并以极低的轻微副作用率。
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Lipid apheresis techniques: current status in Germany.

For long-term lipid apheresis therapy, several different technical systems have been developed which enable effective reduction of LDL cholesterol and other atherogenic lipoproteins, such as Lp(a), with sufficient selectivity and good clinical tolerance. Suitable techniques include whole blood adsorption with polyacrylamide and dextran sulfate cellulose, while primary plasma separation is used for cascade filtration, heparin-induced precipitation, immunoadsorption, silicate gel adsorption, and dextran sulfate cellulose (both techniques). The technical features are described. Only intensive training and experience of the medical personnel guarantees reliable treatment safety of all systems at a very low rate of minor side effects.

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来源期刊
Clinical Research in Cardiology Supplements
Clinical Research in Cardiology Supplements Medicine-Radiology, Nuclear Medicine and Imaging
CiteScore
6.10
自引率
0.00%
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期刊最新文献
Lipoprotein apheresis is an optimal therapeutic option to reduce increased Lp(a) levels. Is lipoprotein(a) a risk factor for ischemic stroke and venous thromboembolism? Lipoprotein(a) and mortality-a high risk relationship. Lipoprotein(a) and proprotein convertase subtilisin/kexin type 9 inhibitors. Lipoprotein(a)-an interdisciplinary challenge.
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