直肠癌患者盆腔放疗前的腹腔镜卵巢移位术:安全性和可行性。

Sami Al-Asari, Alaa Abduljabbar
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摘要

无标签:背景:晚期直肠癌治疗中盆腔放疗导致的不孕是一个主要问题,尤其是对年轻患者而言。目的:该研究调查了放射治疗前腹腔镜卵巢移位术的安全性、可行性和有效性,以及其对治疗局部晚期直肠癌时卵巢功能的影响:方法:对 2003-2007 年间费萨尔国王专科医院和研究中心所有确诊为局部晚期直肠癌、接受腹腔镜卵巢移位术并在术前接受放疗的年轻女性患者进行病历回顾:在研究期间,有三名年龄在 21-27 岁之间的晚期直肠癌患者接受了放疗前腹腔镜卵巢移位术。由于肿瘤继发直肠狭窄,所有患者都需要同时进行腹腔镜转移造口术。一名患者在治疗期间死于转移性疾病。两名患者的卵巢激素水平(FSH 和 LH)正常。一名患者月经正常,另一名患者随访4个月后闭经,但其卵巢激素水平在正常范围内:结论:在晚期直肠癌盆腔放疗前进行腹腔镜卵巢移位术是一种有效且可行的方法,可为面临放疗引起卵巢功能衰竭风险的年轻患者保留卵巢功能。然而,该手术仍未得到广泛应用,建议对合适的患者进行讨论并提出建议。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Laparoscopic ovarian transposition before pelvic radiation in rectal cancer patient: safety and feasibility.

Unlabelled:

Background: Infertility due to pelvic radiation for advanced rectal cancer treatment is a major concern particularly in young patients. Pre-radiation laparoscopic ovarian transposition may offer preservation of ovarian function during the treatment however its use is limited.

Aim: The study investigates the safety, feasibility and effectiveness of pre-radiation laparoscopic ovarian transposition and its effect on ovarian function in the treatment o locally advanced rectal cancer.

Methods: Charts review of all young female patients diagnosed with locally advanced rectal cancer, underwent laparoscopic ovarian transposition, then received preoperative radiotherapy at king Faisal Specialist Hospital and Research Centre between 2003-2007.

Results: During the period studied three single patients age between 21-27 years underwent pre-radiation laparoscopic ovarian transposition for advanced rectal cancer. All required pretreatment laparoscopic diversion stoma due to rectal stricture secondary to tumor that was performed at the same time. One patient died of metastatic disease during treatment. The ovarian hormonal levels (FSH and LH) were normal in two patients. One has had normal menstrual period and other had amenorrhoea after 4 months follow-up however her ovarian hormonal level were within normal limits.

Conclusions: Laparoscopic ovarian transposition before pelvic radiation in advanced rectal cancer treatment is an effective and feasible way of preservation of ovarian function in young patients at risk of radiotherapy induced ovarian failure. However, this procedure is still under used and it is advisable to discuss and propose it to suitable patients.

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