心脏和钾:香蕉共和国。

Ehsan Khan, Christine Spiers, Maria Khan
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引用次数: 8

摘要

钾在维持稳定的心功能中的重要性是一个临床理解的现象。从生理学上讲,钾在心功能中的重要性是通过在心脏中发现的大量不同种类的钾离子通道来描述的,而不是其他离子(如钠和钙)的通道和膜运输机制。钾在心功能的生理稳态控制中很重要,但也与患病状态相关,因为钾相关的影响可能会稳定或破坏心功能。本文旨在提供钾介导的心脏功能的详细了解。这将有助于临床医生评估疾病和药理学操作对钾离子通道的调节如何影响心脏病患者,从而有助于在面临与钾相关的临床问题时做出决策。
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The heart and potassium: a banana republic.

The importance of potassium in maintaining stable cardiac function is a clinically understood phenomenon. Physiologically the importance of potassium in cardiac function is described by the large number of different kinds of potassium ions channels found in the heart compared to channels and membrane transport mechanisms for other ions such as sodium and calcium. Potassium is important in physiological homeostatic control of cardiac function, but is also of relevance to the diseased state, as potassium-related effects may stabilize or destabilize cardiac function. This article aims to provide a detailed understanding of potassium-mediated cardiac function. This will help the clinical practitioner evaluate how modulation of potassium ion channels by disease and pharmacological manipulation affect the cardiac patient, thus aiding in decision making when faced with clinical problems related to potassium.

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