{"title":"葡萄籽多酚在阿尔茨海默病神经病理学中的作用。","authors":"Giulio Maria Pasinetti, Lap Ho","doi":"10.2147/NDS.S6898","DOIUrl":null,"url":null,"abstract":"<p><p>Alzheimer's disease (AD) is an age-related neurodegenerative condition characterized by a progressive decline in cognitive function. AD affects approximately five million people in the US, creating a devastating financial burden on health care costs and an emotional burden on caregivers. To date, there is no cure for AD, so researchers are continually exploring novel avenues for the prevention and treatment of this condition. In this article, we present some findings from our laboratory and those of others on the potential benefits of a grape seed polyphenolic extract (GSPE) for the prevention and treatment of AD, including its chemical composition, bioactivity, bioavailability, safety, and tolerability, and the mechanisms by which it interferes with AD pathogenesis. Findings presented in this review article support the development of GSPE as a preventative and/or therapeutic agent in AD.</p>","PeriodicalId":43423,"journal":{"name":"Nutrition and Dietary Supplements","volume":null,"pages":null},"PeriodicalIF":1.3000,"publicationDate":"2010-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/NDS.S6898","citationCount":"38","resultStr":"{\"title\":\"Role of grape seed polyphenols in Alzheimer's disease neuropathology.\",\"authors\":\"Giulio Maria Pasinetti, Lap Ho\",\"doi\":\"10.2147/NDS.S6898\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Alzheimer's disease (AD) is an age-related neurodegenerative condition characterized by a progressive decline in cognitive function. AD affects approximately five million people in the US, creating a devastating financial burden on health care costs and an emotional burden on caregivers. To date, there is no cure for AD, so researchers are continually exploring novel avenues for the prevention and treatment of this condition. In this article, we present some findings from our laboratory and those of others on the potential benefits of a grape seed polyphenolic extract (GSPE) for the prevention and treatment of AD, including its chemical composition, bioactivity, bioavailability, safety, and tolerability, and the mechanisms by which it interferes with AD pathogenesis. Findings presented in this review article support the development of GSPE as a preventative and/or therapeutic agent in AD.</p>\",\"PeriodicalId\":43423,\"journal\":{\"name\":\"Nutrition and Dietary Supplements\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2010-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.2147/NDS.S6898\",\"citationCount\":\"38\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nutrition and Dietary Supplements\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2147/NDS.S6898\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"NUTRITION & DIETETICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nutrition and Dietary Supplements","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2147/NDS.S6898","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}
Role of grape seed polyphenols in Alzheimer's disease neuropathology.
Alzheimer's disease (AD) is an age-related neurodegenerative condition characterized by a progressive decline in cognitive function. AD affects approximately five million people in the US, creating a devastating financial burden on health care costs and an emotional burden on caregivers. To date, there is no cure for AD, so researchers are continually exploring novel avenues for the prevention and treatment of this condition. In this article, we present some findings from our laboratory and those of others on the potential benefits of a grape seed polyphenolic extract (GSPE) for the prevention and treatment of AD, including its chemical composition, bioactivity, bioavailability, safety, and tolerability, and the mechanisms by which it interferes with AD pathogenesis. Findings presented in this review article support the development of GSPE as a preventative and/or therapeutic agent in AD.
期刊介绍：
Nutrition and Dietary Supplements is an international, peer-reviewed, open access journal focusing on research into nutritional requirements in health and disease, impact on metabolism and the identification and optimal use of dietary strategies and supplements necessary for normal growth and development. Specific topics covered in the journal include: Epidemiology, prevalence of related disorders such as obesity, diabetes, dyslipidemias Biochemistry and cellular metabolism of nutrients Effect of nutrition on metabolic control Impact of hormones and genetics on nutrient handling Identification of cofactors and development of effective supplementation strategies Dietary strategies Behavior modification Consumer and patient adherence, quality of life Public Health Policy & Health Economics.
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