细菌色素prodigiosin及其基因毒性作用。

I D Gur'ianov, N S Karamova, D V Iusupova, O I Gnezdilov, L A Koshkarova
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引用次数: 0

摘要

采用色谱法从粘质沙雷菌ATCC 9986中分离纯化了芥子皂苷制剂。通过薄层色谱、核磁共振光谱和质谱分析,确定了红色素部分为神子红素,并测定了其纯度。最初,研究人员已经确定了鼠伤寒沙门氏菌TA 100细胞中的毒性和基因毒性作用的具体特征以及色素诱导突变的可能性(Ames试验)和哺乳动物红细胞的染色体损伤。
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[Bacterial pigment prodigiosin and its genotoxic effects].

The prodigiosin preparation was isolated and purified from Serratia marcescens ATCC 9986, using chromatographic methods. The analysis of the preparation by TLC, NMR-spectrometry and mass-spectrometry allowed to confirm the red pigment fraction as the prodigiosin and detect its purity. Originally, the specific features of the toxic and genotoxic effects of prodigiosin and the possibility of induction of mutations by pigment in the cells of Salmonella typhimurium TA 100 (Ames test) and chromosome damage of mammalian erythroblasts have been determined.

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