自闭症的言语和语言障碍:来自行为和神经影像学的见解。

Maria Mody, John W Belliveau
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引用次数: 94

摘要

不能发展语言是自闭症的最早征兆之一。考虑到五岁之前的语言能力是自闭症预后最好的预测指标,在非常年幼的儿童中识别这种缺陷的神经特征的能力变得越来越重要。这篇综述巩固了语言发展的言语和前言语前体作为一个框架来检查自闭症谱系障碍中与言语和语言相关的行为和大脑异常。将言语网络的中断与所观察到的社会缺陷联系起来,将为ASD的行为和药物干预提供有希望的目标。
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Speech and Language Impairments in Autism: Insights from Behavior and Neuroimaging.

A failure to develop language is one of the earliest signs of autism. The ability to identify the neural signature of this deficit in very young children has become increasingly important, given that the presence of speech before five years of age is the strongest predictor for better outcomes in autism. This review consolidates what is known about verbal and preverbal precursors of language development as a framework for examining behavioral and brain anomalies related to speech and language in autism spectrum disorders. Relating the disruptions in the speech network to the social deficits observed will provide promising targets for behavioral and pharmacological interventions in ASD.

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