{"title":"自闭症的言语和语言障碍:来自行为和神经影像学的见解。","authors":"Maria Mody, John W Belliveau","doi":"10.7156/v5i3p157","DOIUrl":null,"url":null,"abstract":"<p><p>A failure to develop language is one of the earliest signs of autism. The ability to identify the neural signature of this deficit in very young children has become increasingly important, given that the presence of speech before five years of age is the strongest predictor for better outcomes in autism. This review consolidates what is known about verbal and preverbal precursors of language development as a framework for examining behavioral and brain anomalies related to speech and language in autism spectrum disorders. Relating the disruptions in the speech network to the social deficits observed will provide promising targets for behavioral and pharmacological interventions in ASD.</p>","PeriodicalId":19338,"journal":{"name":"North American journal of medicine & science","volume":"5 3","pages":"157-161"},"PeriodicalIF":0.0000,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3862077/pdf/nihms533441.pdf","citationCount":"94","resultStr":"{\"title\":\"Speech and Language Impairments in Autism: Insights from Behavior and Neuroimaging.\",\"authors\":\"Maria Mody, John W Belliveau\",\"doi\":\"10.7156/v5i3p157\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>A failure to develop language is one of the earliest signs of autism. The ability to identify the neural signature of this deficit in very young children has become increasingly important, given that the presence of speech before five years of age is the strongest predictor for better outcomes in autism. This review consolidates what is known about verbal and preverbal precursors of language development as a framework for examining behavioral and brain anomalies related to speech and language in autism spectrum disorders. Relating the disruptions in the speech network to the social deficits observed will provide promising targets for behavioral and pharmacological interventions in ASD.</p>\",\"PeriodicalId\":19338,\"journal\":{\"name\":\"North American journal of medicine & science\",\"volume\":\"5 3\",\"pages\":\"157-161\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2013-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3862077/pdf/nihms533441.pdf\",\"citationCount\":\"94\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"North American journal of medicine & science\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.7156/v5i3p157\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"North American journal of medicine & science","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.7156/v5i3p157","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Speech and Language Impairments in Autism: Insights from Behavior and Neuroimaging.
A failure to develop language is one of the earliest signs of autism. The ability to identify the neural signature of this deficit in very young children has become increasingly important, given that the presence of speech before five years of age is the strongest predictor for better outcomes in autism. This review consolidates what is known about verbal and preverbal precursors of language development as a framework for examining behavioral and brain anomalies related to speech and language in autism spectrum disorders. Relating the disruptions in the speech network to the social deficits observed will provide promising targets for behavioral and pharmacological interventions in ASD.