吗啡犬尿氨酸通路的免疫组化研究。

IF 2.7 Q3 NEUROSCIENCES International Journal of Tryptophan Research Pub Date : 2013-12-23 eCollection Date: 2013-01-01 DOI:10.4137/IJTR.S13371

Rowland Noakes, Nick Mellick

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引用次数: 4

摘要

皮肤硬化，类似于皮下痣，是嗜酸性筋膜炎和嗜酸性肌痛综合征的特征，这两种情况下犬尿氨酸途径被激活。为了研究睡眠病中犬尿氨酸通路激活的可能性，我们对3例睡眠病患者的相关部位和非相关部位进行了皮肤活检。免疫组化染色检测喹啉酸和吲哚胺2,3-双加氧酶(IDO)。

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Immunohistochemical studies of the kynurenine pathway in morphea.

Cutaneous sclerosis, resembling that seen in subcutaneous morphea, is a feature of eosinophilic fasciitis and eosinophilia-myalgia syndrome, two conditions in which the kynurenine pathway is known to be activated. To investigate the possibility of activation of the kynurenine pathway in morphea, skin biopsies were taken from involved and non-involved sites in a series of three patients with morphea. Immunohistochemical stains for quinolinic acid and indoleamine 2,3-dioxygenase (IDO) were performed.

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