在遗传和降脂药物和饮食网络(GOLDN)研究中,非诺贝特治疗前后高甘油三酯血症男性和女性对高脂肪膳食的餐后反应的比较

Stephen P Glasser, Mary K Wojczynski, A I Oberman, Edmond K Kabagambe, Michael Y Tsai, Jose M Ordovas, Robert J Straka, Donna K Arnett
{"title":"在遗传和降脂药物和饮食网络(GOLDN)研究中,非诺贝特治疗前后高甘油三酯血症男性和女性对高脂肪膳食的餐后反应的比较","authors":"Stephen P Glasser,&nbsp;Mary K Wojczynski,&nbsp;A I Oberman,&nbsp;Edmond K Kabagambe,&nbsp;Michael Y Tsai,&nbsp;Jose M Ordovas,&nbsp;Robert J Straka,&nbsp;Donna K Arnett","doi":"10.3814/2010/485146","DOIUrl":null,"url":null,"abstract":"<p><strong>Context: </strong>The fenofibrate effect on the subclass size distribution of lipoproteins before and after a high-fat challenge is not well studied.</p><p><strong>Objective: </strong>To characterize the baseline and post-prandial response (PPL) to a high-fat challenge following fenofibrate therapy, on changes in LDL, HDL, and VLDL particle subclasses, number, and size in 271 hypertriglyceridemic participants.</p><p><strong>Methods: </strong>Participants from the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) study who conducted PPL studies both before and after three weeks of fenofibrate (160 mg/d) treatment were analyzed. Particle size distributions were determined using nuclear magnetic resonance imaging, and lipid determinations were measured at fasting (0 hr), 3.5 hours, and 6 hours after ingestion of a standardized high-fat meal. Analyses were stratified by gender. Changes in particle subclass distributions were assessed using repeated measures analysis of variance adjusted for pedigree.</p><p><strong>Results: </strong>Before PPL, fenofibrate in men (adjusted for age, field center, smoking status, diabetes, and weight circumference) lowered fasting and postprandial VLDL primarily due to reductions in postprandial levels of large and medium VLDL particles (9 SE +/-0.7 to 4 +/-0.4 and 78 / -4 to 36 / -3 nmol/L both <i>P</i> < .0001, resp.). Fenofibrate also reduced fasting and postprandial total LDL particles, primarily a result of reduced small LDL particles (1497 = / - 37 to 1088 = / - 36 nmol/L, <i>P</i> < .0001). Directional changes were similar in men and women but the magnitude of change was different for some parameters.</p><p><strong>Conclusion: </strong>Fenofibrate treatment resulted in a lower triglyceride excursion following a high-fat meal. This investigation provides new knowledge of the magnitude and time course of fenofibrate induced attenuation of Lipoprotein subclass size distribution following a postprandial lipid challenge.</p>","PeriodicalId":90346,"journal":{"name":"SRX pharmacology","volume":"2010 ","pages":"485146"},"PeriodicalIF":0.0000,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067904/pdf/nihms-499566.pdf","citationCount":"2","resultStr":"{\"title\":\"Comparison of Postprandial Responses to a High-Fat Meal in Hypertriglyceridemic Men and Women before and after Treatment with Fenofibrate in the Genetics and Lipid Lowering Drugs and Diet Network (GOLDN) Study.\",\"authors\":\"Stephen P Glasser,&nbsp;Mary K Wojczynski,&nbsp;A I Oberman,&nbsp;Edmond K Kabagambe,&nbsp;Michael Y Tsai,&nbsp;Jose M Ordovas,&nbsp;Robert J Straka,&nbsp;Donna K Arnett\",\"doi\":\"10.3814/2010/485146\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Context: </strong>The fenofibrate effect on the subclass size distribution of lipoproteins before and after a high-fat challenge is not well studied.</p><p><strong>Objective: </strong>To characterize the baseline and post-prandial response (PPL) to a high-fat challenge following fenofibrate therapy, on changes in LDL, HDL, and VLDL particle subclasses, number, and size in 271 hypertriglyceridemic participants.</p><p><strong>Methods: </strong>Participants from the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) study who conducted PPL studies both before and after three weeks of fenofibrate (160 mg/d) treatment were analyzed. Particle size distributions were determined using nuclear magnetic resonance imaging, and lipid determinations were measured at fasting (0 hr), 3.5 hours, and 6 hours after ingestion of a standardized high-fat meal. Analyses were stratified by gender. Changes in particle subclass distributions were assessed using repeated measures analysis of variance adjusted for pedigree.</p><p><strong>Results: </strong>Before PPL, fenofibrate in men (adjusted for age, field center, smoking status, diabetes, and weight circumference) lowered fasting and postprandial VLDL primarily due to reductions in postprandial levels of large and medium VLDL particles (9 SE +/-0.7 to 4 +/-0.4 and 78 / -4 to 36 / -3 nmol/L both <i>P</i> < .0001, resp.). Fenofibrate also reduced fasting and postprandial total LDL particles, primarily a result of reduced small LDL particles (1497 = / - 37 to 1088 = / - 36 nmol/L, <i>P</i> < .0001). Directional changes were similar in men and women but the magnitude of change was different for some parameters.</p><p><strong>Conclusion: </strong>Fenofibrate treatment resulted in a lower triglyceride excursion following a high-fat meal. This investigation provides new knowledge of the magnitude and time course of fenofibrate induced attenuation of Lipoprotein subclass size distribution following a postprandial lipid challenge.</p>\",\"PeriodicalId\":90346,\"journal\":{\"name\":\"SRX pharmacology\",\"volume\":\"2010 \",\"pages\":\"485146\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2010-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067904/pdf/nihms-499566.pdf\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"SRX pharmacology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3814/2010/485146\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"SRX pharmacology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3814/2010/485146","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 2

摘要

背景:非诺贝特对高脂肪攻击前后脂蛋白亚类大小分布的影响尚未得到很好的研究。目的:描述271名高甘油三酯血症患者在非诺贝特治疗后对高脂肪挑战的基线和餐后反应(PPL), LDL、HDL和VLDL颗粒亚类、数量和大小的变化。方法:对来自降脂药物和饮食网络遗传学(GOLDN)研究的参与者在非诺贝特(160 mg/d)治疗三周前后进行PPL研究进行分析。使用核磁共振成像确定颗粒大小分布,并在空腹(0小时)、3.5小时和摄入标准高脂肪膳食后6小时测量脂质测定。分析按性别分层。颗粒亚类分布的变化是通过重复测量分析来评估的。结果:在PPL之前,男性非诺贝特(根据年龄、场地中心、吸烟状况、糖尿病和体重围度调整)降低了空腹和餐后VLDL,主要是由于餐后大VLDL颗粒和中等VLDL颗粒水平的降低(9 SE +/-0.7至4 +/-0.4和78 / -4至36 / -3 nmol/L, P < 0.0001,分别)。非诺贝特还减少了空腹和餐后总LDL颗粒,主要是由于减少了小LDL颗粒(1497 = / - 37至1088 = / - 36 nmol/L, P < 0.0001)。男性和女性的方向性变化相似,但某些参数的变化幅度不同。结论:非诺贝特治疗导致高脂肪饮食后甘油三酯偏移降低。这项研究提供了非诺贝特诱导的餐后脂质激发后脂蛋白亚类大小分布衰减的幅度和时间过程的新知识。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

摘要图片

摘要图片

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Comparison of Postprandial Responses to a High-Fat Meal in Hypertriglyceridemic Men and Women before and after Treatment with Fenofibrate in the Genetics and Lipid Lowering Drugs and Diet Network (GOLDN) Study.

Context: The fenofibrate effect on the subclass size distribution of lipoproteins before and after a high-fat challenge is not well studied.

Objective: To characterize the baseline and post-prandial response (PPL) to a high-fat challenge following fenofibrate therapy, on changes in LDL, HDL, and VLDL particle subclasses, number, and size in 271 hypertriglyceridemic participants.

Methods: Participants from the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) study who conducted PPL studies both before and after three weeks of fenofibrate (160 mg/d) treatment were analyzed. Particle size distributions were determined using nuclear magnetic resonance imaging, and lipid determinations were measured at fasting (0 hr), 3.5 hours, and 6 hours after ingestion of a standardized high-fat meal. Analyses were stratified by gender. Changes in particle subclass distributions were assessed using repeated measures analysis of variance adjusted for pedigree.

Results: Before PPL, fenofibrate in men (adjusted for age, field center, smoking status, diabetes, and weight circumference) lowered fasting and postprandial VLDL primarily due to reductions in postprandial levels of large and medium VLDL particles (9 SE +/-0.7 to 4 +/-0.4 and 78 / -4 to 36 / -3 nmol/L both P < .0001, resp.). Fenofibrate also reduced fasting and postprandial total LDL particles, primarily a result of reduced small LDL particles (1497 = / - 37 to 1088 = / - 36 nmol/L, P < .0001). Directional changes were similar in men and women but the magnitude of change was different for some parameters.

Conclusion: Fenofibrate treatment resulted in a lower triglyceride excursion following a high-fat meal. This investigation provides new knowledge of the magnitude and time course of fenofibrate induced attenuation of Lipoprotein subclass size distribution following a postprandial lipid challenge.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
The Thermodynamic Dissociation Constants of Clotrimazole, Terbinafine HCL, Acetylsalicylic Acid, Salicylic Acid, and Galanthamine by the Nonlinear Regression of Multiwavelength Spectrophotometric pH-Titration Data The Utility of Rapid Microbiological and Molecular Techniques in Optimizing Antimicrobial Therapy Recent Progress in the pKa Estimation of Druglike Molecules by the Nonlinear Regression of Multiwavelength Spectrophotometric pH-Titration Data Individualization of 5-Fluorouracil in the Treatment of Colorectal Cancer Sustain Released Bupropion in the Treatment of Tricotillomania: Outpatient Follow Up Survey
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1