Zhao-Hua Zhou, Namita Kumari, Jennifer Catalano, Sergei Nekhai, Jasen Wise, Kenneth M Yamada, Subhash Dhawan
{"title":"血红素加氧酶-1介导的宿主细胞反应抑制前列腺癌细胞对逆转录病毒感染的易感性并延缓其增殖。","authors":"Zhao-Hua Zhou, Namita Kumari, Jennifer Catalano, Sergei Nekhai, Jasen Wise, Kenneth M Yamada, Subhash Dhawan","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Xenotropic murine leukemia virus-related virus (XMRV) resembles endogenous murine leukemia virus and was used in this study as a model for a new retrovirus infecting human cells. We demonstrate that induction of an HO-1-mediated host cell response inhibited the susceptibility of LNCaP prostate cancer cells to XMRV infection and efficiently retarded the growth of these prostate cancer cells. Our studies delineate a role of HO-1 in the host defense against retroviral infections and may provide novel therapeutic strategies for the treatment of HO-1-sensitive prostate cancer.</p>","PeriodicalId":34989,"journal":{"name":"Current Trends in Immunology","volume":"14 ","pages":"53-56"},"PeriodicalIF":0.0000,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302767/pdf/nihms564211.pdf","citationCount":"0","resultStr":"{\"title\":\"Heme oxygenase-1-mediated host cell response inhibits the susceptibility of prostate cancer cells to retroviral infection and retards their proliferation.\",\"authors\":\"Zhao-Hua Zhou, Namita Kumari, Jennifer Catalano, Sergei Nekhai, Jasen Wise, Kenneth M Yamada, Subhash Dhawan\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Xenotropic murine leukemia virus-related virus (XMRV) resembles endogenous murine leukemia virus and was used in this study as a model for a new retrovirus infecting human cells. We demonstrate that induction of an HO-1-mediated host cell response inhibited the susceptibility of LNCaP prostate cancer cells to XMRV infection and efficiently retarded the growth of these prostate cancer cells. Our studies delineate a role of HO-1 in the host defense against retroviral infections and may provide novel therapeutic strategies for the treatment of HO-1-sensitive prostate cancer.</p>\",\"PeriodicalId\":34989,\"journal\":{\"name\":\"Current Trends in Immunology\",\"volume\":\"14 \",\"pages\":\"53-56\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2013-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302767/pdf/nihms564211.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Trends in Immunology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Trends in Immunology","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
摘要
异嗜性小鼠白血病病毒相关病毒(Xenotropic murine leukemia virus related virus, XMRV)类似于内源性小鼠白血病病毒，在本研究中被用作一种新的逆转录病毒感染人类细胞的模型。我们证明了ho -1介导的宿主细胞反应的诱导抑制了LNCaP前列腺癌细胞对XMRV感染的易感性，并有效地延缓了这些前列腺癌细胞的生长。我们的研究描述了HO-1在宿主防御逆转录病毒感染中的作用，并可能为HO-1敏感前列腺癌的治疗提供新的治疗策略。
Heme oxygenase-1-mediated host cell response inhibits the susceptibility of prostate cancer cells to retroviral infection and retards their proliferation.
Xenotropic murine leukemia virus-related virus (XMRV) resembles endogenous murine leukemia virus and was used in this study as a model for a new retrovirus infecting human cells. We demonstrate that induction of an HO-1-mediated host cell response inhibited the susceptibility of LNCaP prostate cancer cells to XMRV infection and efficiently retarded the growth of these prostate cancer cells. Our studies delineate a role of HO-1 in the host defense against retroviral infections and may provide novel therapeutic strategies for the treatment of HO-1-sensitive prostate cancer.
期刊介绍：
Computers and Electronics in Agriculture provides international coverage of advances in the development and application of computer hardware, software, electronic instrumentation, and control systems for solving problems in agriculture, including agronomy, horticulture (in both its food and amenity aspects), forestry, aquaculture, and animal/livestock farming. The journal publishes original papers, reviews, and applications notes on topics pertaining to advances in the use of computers or electronics in plant or animal agricultural production, including agricultural soils, water, pests, controlled environments, structures, and wastes, as well as the plants and animals themselves. Post-harvest operations considered part of agriculture (such as drying, storage, logistics, production assessment, trimming and separation of plant and animal material) are also covered. Relevant areas of technology include artificial intelligence, sensors, machine vision, robotics, networking, and simulation modelling.
分享
京公网安备 11010802042870号
京ICP备2023020795号-1
求助内容：
应助结果提醒方式：
扫码关注我们
