评价口服紫锥菊水乙醇提取物对犬免疫系统的影响

S. Torkan, F. Khamesipour, S. Katsande
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引用次数: 12

摘要

本研究旨在评估口服紫锥菊水乙醇提取物对狗免疫系统的影响。这项研究是在转介到兽医诊所的14只狗身上进行的。这些狗被随机分配到两个平等的治疗组。第一组给予5%紫锥菊水乙醇提取物1 ml,每天2次,连续2个月;第二组给予安慰剂(水)。在第0、30和60天进行血液学和免疫学测试。进行血液检查,包括细胞体积(PCV)、血红蛋白(Hb)、红细胞计数(RBC)、白细胞计数(WBC)、中性粒细胞(Nut)、淋巴细胞(Lym)、单核细胞(Mon)、嗜酸性粒细胞(Eos)、嗜碱性粒细胞(Baso)和B细胞计数。此外,从血液样本中测量安全系数IgM和吞噬率和吞噬细胞的百分比。结果表明,紫锥菊组PCV、Hb、RBC、WBC、Lym、Nut、吞噬率和IgM均显著升高(P <0.05)。此外,还观察到紫锥菊对免疫系统的积极作用。服用紫锥菊组的HTC、RBC、Hb随时间变化显著,吞噬率和IgM (P <0.05)。研究表明,这些提取物可能具有明显的免疫刺激活性。然而,需要进一步的研究来证实这些发现。
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Evaluating the effect of oral administration of Echinacea hydroethanolic extract on the immune system in dog

  1. This study was designed to evaluate the effects of oral administration of Echinacea hydroethanolic extract on the dog's immune system.
  2. The study was performed on 14 dogs that were referred to the veterinary clinic. These dogs were randomly allocated to two equal treatment groups. The first group received 1 ml of 5% Echinacea hydroethanolic extract two times a day for 2 months, and the second group received a placebo (water). To do haematology and immunology tests, the dogs were bled on days 0, 30 and 60. Blood tests, including packed cell volume (PCV), haemoglobin (Hb), red blood cell count (RBC), white blood cell count (WBC), counting neutrophils (Nut), lymphocytes (Lym), monocytes (Mon), eosinophils (Eos), basophils (Baso) and B cell, were performed. Furthermore, safety factor IgM and per cent of phagocytosis and phagocyte were measured from the blood sample.
  3. The results showed that in the group which received Echinacea PCV, Hb, RBC count, WBC count, Lym, Nut, the per cent of phagocytosis and IgM significantly increased (P < 0.05). Moreover, positive effects of Echinacea plant on the immune system were observed. There was a significant change in HTC, RBC, Hb over time in the group that received Echinacea and the per cent of phagocytosis and IgM (P < 0.05).
  4. The study establishes that these extracts might have appreciable immunostimulatory activity. However, further studies are required to confirm these findings.
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Issue Information Autonomic and Autacoid Pharmacology: Goodbye and thank you Attenuation of the anti-contractile effect of cooling in the rat aorta by perivascular adipose tissue Retraction: Dopamine receptor immunohistochemistry in the rat choroid plexus. Issue Information
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