复发性气胸的意外原因。

IF 4.4 Q1 PATHOLOGY PATHOLOGICA Pub Date : 2022-08-01 DOI:10.32074/1591-951X-377
Giulio Rossi, Anna Farnedi, Fabio Davoli, Adolfo D'Agostino, Tommaso Bizzarro, Paride D'Angelo, Rita Sargiacomo
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引用次数: 1

摘要

胸区是滑膜肉瘤最常见的内脏部位,通常累及肺和胸膜,呈大的实性肿块。我们在此报告一个57岁的男性复发性气胸和在舌部的局部大疱。病变通过视频辅助胸腔镜手术(VATS)楔形切除术切除,令人惊讶的是由一个单眼囊肿组成,纤维壁由纵向增生的外观单调,致密的单形梭形细胞混合,弥漫性表达EMA, CD99, CD56,并局部染色细胞角蛋白。荧光原位杂交显示SYT重排的存在,诊断为肺囊性单相滑膜肉瘤。文献中仅有少数类似病例报道,主要发生在年轻男性成年人中。对所有从气胸切除的组织进行细致的检查是怀疑这种极具挑战性的疾病的先决条件,而免疫分子研究是实现正确诊断的必要条件。
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An unexpected cause of recurrent pneumothorax.

The thoracic district is the most frequent visceral location of synovial sarcoma, generally involving lung and pleura as a large solid mass. We present herein a 57-year-old man with recurrent pneumothorax and a localized bulla at the lingula. The lesion was excised by a Video-Assisted-Thoracoscopic-Surgery (VATS) wedge resection and surprisingly consisted of a unilocular cyst with fibrous wall intermingled by a longitudinal proliferation of bland-looking, dense, monomorphic spindle cells diffusely expressing EMA, CD99, CD56 and focally staining with cytokeratins. Fluorescent in situ hybridization demonstrated the presence of SYT rearrangement and a diagnosis of pulmonary cystic monophasic synovial sarcoma was made. Only few similar cases have been reported in literature, mainly occurring in young male adults. A meticulous examination of all resected tissue from pneumothorax is the prerequisite to suspect this extremely challenging condition, while immuno-molecular studies are mandatory to achieve the correct diagnosis.

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来源期刊
PATHOLOGICA
PATHOLOGICA PATHOLOGY-
CiteScore
5.90
自引率
5.70%
发文量
108
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