热敏离子通道TRPV4在免疫系统中的功能及调控。

4区 生物学 Q4 Biochemistry, Genetics and Molecular Biology Current topics in membranes Pub Date : 2022-01-01 Epub Date: 2022-08-01 DOI:10.1016/bs.ctm.2022.07.002
Tusar Kanta Acharya, Ram Prasad Sahu, Satish Kumar, Shamit Kumar, Tejas Pravin Rokade, Ranabir Chakraborty, Nishant Kumar Dubey, Deep Shikha, Saurabh Chawla, Chandan Goswami
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引用次数: 2

摘要

瞬时受体电位香草样蛋白亚型4 (TRPV4)是一种六跨膜蛋白,作为非选择性Ca2+通道。值得注意的是,TRPV4存在于从低等真核生物到人类的几乎所有动物中,并在多种组织和细胞类型中表达。因此,TRPV4在几种类型的免疫细胞中内源性表达,这些免疫细胞代表了高等生物的先天免疫系统和适应性免疫系统。已知TRPV4可被生理温度激活,这表明它作为分子温度传感器,在温度依赖性免疫激活中起关键作用。它也被多种内源性配体、脂质代谢物、物理和机械刺激激活。TRPV4在包括T细胞和巨噬细胞在内的多种免疫细胞中的表达和功能也受到多种促炎和抗炎化合物的调节。几个实验室的结果表明,TRPV4参与了免疫激活,这是一种具有进化意义的现象。由于其在神经元和免疫系统中的多种作用,TRPV4是几种免疫相关疾病的潜在治疗靶点。
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Function and regulation of thermosensitive ion channel TRPV4 in the immune system.

Transient receptor potential vanilloid sub-type 4 (TRPV4) is a six transmembrane protein that acts as a non-selective Ca2+ channel. Notably, TRPV4 is present in almost all animals, from lower eukaryotes to humans and is expressed in diverse tissue and cell types. Accordingly, TRPV4 is endogenously expressed in several types of immune cells that represent both innate and adaptive immune systems of higher organism. TRPV4 is known to be activated by physiological temperature, suggesting that it acts as a molecular temperature sensor and thus plays a key role in temperature-dependent immune activation. It is also activated by diverse endogenous ligands, lipid metabolites, physical and mechanical stimuli. Both expression and function of TRPV4 in various immune cells, including T cells and macrophages, are also modulated by multiple pro- and anti-inflammatory compounds. The results from several laboratories suggest that TRPV4 is involved in the immune activation, a phenomenon with evolutionary significance. Because of its diverse engagement in the neuronal and immune systems, TRPV4 is a potential therapeutic target for several immune-related disorders.

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来源期刊
Current topics in membranes
Current topics in membranes 生物-生化与分子生物学
CiteScore
3.50
自引率
0.00%
发文量
10
审稿时长
>12 weeks
期刊介绍: Current Topics in Membranes provides a systematic, comprehensive, and rigorous approach to specific topics relevant to the study of cellular membranes. Each volume is a guest edited compendium of membrane biology.
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