O V Payushina, N N Butorina, O N Sheveleva, E I Domaratskaya
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[Comparative Analysis of Subpopulations of Mesenchymal Stromal Cells of the Bone Marrow and Fetal Liver Differing in Sensitivity to 5-Fluorouracil].
It is shown that the effect of 5-fluorouracil (5-FU) on mesenchymal stromal cells (MSCs) of the bone marrow and fetal liver of the rat increases the population of cells with a reduced proliferative potential. It is shown that, in the course of passaging, the 5-FU-resistant MSCs of the bone marrow and fetal liver lose their ability to differentiate in the osteogenic direction more and less rapidly, respectively, than the 5-FU-sensitive MSCs.
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