[超低频低强度电磁辐射下的修复性骨生成与血管生成]。

Y M Iryanov, N A Kiryanov
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引用次数: 3

摘要

背景:不同病理状态下修复性骨组织再生的非药物矫正是现代医学最现实的问题之一。目的:观察超高频低强度电磁辐射对骨融合术骨折治疗中修复性成骨和血管生成的影响。方法:采用非随机对照研究。在大鼠胫骨骨折实验中,我们分别在对照组和实验组进行骨碎片复位和固定。实验组动物断裂带暴露在超高频低强度电磁辐射下。对照组进行暴露模拟。采用x线摄影、光镜和电子显微镜、x射线电子探针微量分析等方法对手术骨进行检查。结果:超高频电磁辐射在骨折治疗中刺激肥大细胞的分泌活性和脱颗粒,使微循环床血管通透性增加,内皮细胞迁移表型表达,提供血管内内皮生长形成,激活修复性成骨和血管生成,而骨折修复成为主要类型之一。28天内确定全骨膜、中间骨和骨内骨愈合情况。结论:在超高频电磁辐射治疗骨折的疗效中,我们可以检测到肥大细胞分泌活性的刺激和血管内活化。
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[Reparative Osteogenesis and Angiogenesis in Low Intensity Electromagnetic Radiation of Ultra-High Frequency].

Background: Non-drug correction of reparative bone tissue regeneration in different pathological states - one of the most actual problems of modern medicine.

Objective: Our aim was to conduct morphological analysis of the influence of electromagnetic radiation of ultra-high frequency and low intensity on reparative osteogenesis and angiogenesis in fracture treatment under transosseous osteosynthesis.

Methods: A controlled nonrandomized study was carried out. In the experiment conducted on rats we modeled tibial fracture with reposition and fixation of the bone fragments both in control and experimental groups. In the animals of the experimental group the fracture zone was exposed to low intensity electromagnetic radiation of ultra-high frequency. Exposure simulation was performed in the control group. The operated bones were examined using radiography, light and electronic microscopy, X-ray electronic probe microanalysis.

Results: It has been established that electromagnetic radiation of ultra-high frequency sessions in fracture treatment stimulate secretory activity and degranulation of mast cells, produce microcirculatory bed vascular permeability increase, endotheliocyte migration phenotype expression, provide endovascular endothelial outgrowth formation, activate reparative osteogenesis and angiogenesis while fracture reparation becomes the one of the primary type. The full periosteal, intermediary and intraosteal bone union was defined in 28 days.

Conclusion: Among the therapeutic benefits of electromagnetic radiation of ultra-high frequency in fracture treatment we can detect mast cell secretorv activity stimulation and endovascular anziozenesis activation.

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来源期刊
CiteScore
1.50
自引率
0.00%
发文量
31
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