先天淋巴样细胞前体。

IF 26.9 1区 医学 Q1 IMMUNOLOGY Annual review of immunology Pub Date : 2016-05-20 DOI:10.1146/annurev-immunol-041015-055549
Isabel E Ishizuka, Michael G Constantinides, Herman Gudjonson, Albert Bendelac
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引用次数: 53

摘要

组织驻留的先天淋巴细胞群影响不同形式的1、2和3型免疫的发现;组织修复;免疫调节改变了我们对粘膜免疫和过敏的理解。这些种群的复杂性以及复杂的冗余和可塑性问题提出了关于它们确切的谱系关系的有趣问题。在这里,我们回顾了从早期淋巴样前体绘制这些谱系出现的进展。我们讨论了一种常见的先天淋巴样细胞前体的鉴定,其特征是转录因子PLZF的瞬时表达,以及先天淋巴样细胞与传统自然杀伤细胞和淋巴组织诱导细胞的谱系关系。我们还回顾了对指导这些谱系发展的转录因子网络的快速增长的理解。
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The Innate Lymphoid Cell Precursor.

The discovery of tissue-resident innate lymphoid cell populations effecting different forms of type 1, 2, and 3 immunity; tissue repair; and immune regulation has transformed our understanding of mucosal immunity and allergy. The emerging complexity of these populations along with compounding issues of redundancy and plasticity raise intriguing questions about their precise lineage relationship. Here we review advances in mapping the emergence of these lineages from early lymphoid precursors. We discuss the identification of a common innate lymphoid cell precursor characterized by transient expression of the transcription factor PLZF, and the lineage relationships of innate lymphoid cells with conventional natural killer cells and lymphoid tissue inducer cells. We also review the rapidly growing understanding of the network of transcription factors that direct the development of these lineages.

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来源期刊
Annual review of immunology
Annual review of immunology 医学-免疫学
CiteScore
57.20
自引率
0.70%
发文量
29
期刊介绍: The Annual Review of Immunology, in publication since 1983, focuses on basic immune mechanisms and molecular basis of immune diseases in humans. Topics include innate and adaptive immunity; immune cell development and differentiation; immune control of pathogens (viruses, bacteria, parasites) and cancer; and human immunodeficiency and autoimmune diseases. The current volume of this journal has been converted from gated to open access through Annual Reviews' Subscribe to Open program, with all articles published under a CC BY license.
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