[大鼠坐骨神经胚胎新皮质同种异体移植物中含有不同神经递质的神经元]。

E S Petrova
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引用次数: 0

摘要

采用以下免疫组织化学标记物鉴定Wistar大鼠新皮质和受损神经中发育的新皮质间神经元亚群:gaba能神经细胞的谷氨酸脱羧酶(GAD 67)、no -合成酶(NOS)、胆碱能细胞的胆碱乙酰转移酶(ChAT)和儿茶酚胺能结构的酪氨酸羟化酶。术后28天,在移植物中检测到个体GAD - 67-ir、NO-ir、ChAT-ir和极少数TH-ir细胞。结果表明,移植物单位面积内GAD 67-ir神经元数量少于大鼠新皮质P20。
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[Neurons with Different Neurotransmitters in Embryonic Neocortical Allografts in the Rat Sciatic Nerve].

Different subsets of interneurons in the Wistar rat neocortex and in neocortical transplants developing in a damaged nerve were identified by the following immunohistochemical markers: glutamate decarboxylase (GAD 67) for GABAergic nerve cells, NO-synthase (NOS) for NO-ergic neurons, choline acetyltransferase (ChAT) for cholinergic cells, and tyrosine hydroxylase for catecholaminergic structures. Twenty-eight days after surgery, individual GAD 67-ir, NO-ir, ChAT-ir, and very rarely TH-ir cells were detected in the graft. It was shown that the number of GAD 67-ir neurons per unit area in the grafts was less than in the rat neocortex P20.

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