[ppar介导长链脂肪酸调节能量代谢]。

生理科学进展 Pub Date : 2016-02-01

Yao Yan, Zong-Bao Wang, Chao-Ke Tang

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引用次数: 0

摘要

ppar - α主要在肝脏中表达，通过诱导β -氧化和生酮基因来增加LCFAs和成纤维细胞生长因子21的效用，对饥饿的代谢适应至关重要。ppar - δ在骨骼肌禁食和耐力运动中诱导LCFA氧化基因。PPAR-delta还通过诱导FOXO1和pgc1 - α调节葡萄糖代谢和线粒体生物发生。ppar - γ可以诱导LCFAs作为甘油三酯在脂肪细胞中储存的途径。脂联素，ppar - γ的另一个重要靶点可能维持脂肪细胞之间的胰岛素敏感性。现就ppar介导长链脂肪酸对能量代谢的调节进行综述。

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[PPARs Mediate the Regulation of Energy Metabolism By Long-Chain Fatty Acids].

PPAR-alpha expressed primarily in liver is essential for metabolic adaptation to starvation by inducing genes for beta-oxidation and ketogenesis to increase the utility of LCFAs and fibroblast growth factor 21. PPAR-delta induces genes for LCFA oxidation during fasting and endurance exercise in skeletal muscle. PPAR-delta also regulates glucose metabolism and mitochondrial biogenesis by inducing FOXO1 and PGC1-alpha. PPAR-gamma can induces the pathways to store LCFAs as triglycerides in adipocytes. Adiponectin, another important target of PPAR-gamma may maintain insulin sensitivity between adipocytes. The present review summarize that PPARs mediate the regulation of energy metabolism by long-chain fatty acids.

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来源期刊

生理科学进展

自引率

0.00%

发文量

5953

期刊介绍： Progress in Physiological Sciences is a bimonthly academic journal co-sponsored by Chinese Association for Science and Technology, Chinese Physiological Society and Peking University. It was founded in March 1957. China Core Journal of Science and Technology, China Core Journal of Medicine and Health, Statistical source journal of Chinese Academic Journal Impact Factor Annual Report, China Science Citation Database CSCD (1996-2018); Overview of Key Chinese Core Journals of Peking University (1992-2020, 2023-), It has been reported by China Journal Network, China Academic Journals (Optical Disc Edition), China Biomedical Citation Database CMCI, Science and Technology Journals World Impact Index (WJCI) (2022), Wanfang Data Resource System digital Journal Group (China Core Journal Database); American Medical Index (IM), American Chemical Abstracts (CA), etc. Progress in Physiological Sciences is published at home and abroad. The journal comprehensively reports the new progress in physiological sciences at home and abroad, and publishes review papers related to physiological sciences, namely physiology, biochemistry and molecular biology, pharmacology, pathophysiology, biophysics, nutrition, etc.