正常血压Wistar-Kyoto大鼠对高盐负荷的抗利尿和抗尿反应:α - 1a肾上腺素受体的作用

Autonomic and Autacoid Pharmacology Pub Date : 2017-03-23 DOI:10.1111/aap.12053

R. N. Kazi, M. A. Sattar, E. J. Johns

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引用次数: 1

摘要

肾脏肾上腺素能反应的改变已被认为是高盐摄入的病理生理反应。本研究旨在探讨6周高盐饮食对正常Wistar Kyoto大鼠α 1a -肾上腺素能受体调节肾小管抗尿和抗利尿反应的影响。为了达到上述目的，采用菊粉清除率法测定了在5-甲基脲地尔(5-MeU)不存在和不存在的情况下，对苯肾上腺素的抗尿钠和抗利尿反应。同时测量全身平均动脉血压和肾脏血流动力学。Wistar-Kyoto (WKY)大鼠高盐摄入6周后，平均动脉血压没有显著升高。高盐饮食组(WKYHNa)大鼠的绝对钠排泄量和部分钠排泄量均显著增加。α α -肾上腺素能素在正常钠饮食(WKYNNa)下Wistar Kyoto大鼠肾小管抗尿和抗利尿反应中有显著参与。然而，α 1a -肾上腺素能受体在高盐饮食WKY大鼠肾小管重吸收反应中起的作用很小。

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Antidiuretic and antinatriuretic response to high salt load in normotensive Wistar-Kyoto rats: Role of alpha-1A-adrenoreceptors

Altered renal adrenergic responses have been recognized as pathophysiological responses to high salt intake. This study aims to investigate the influence of 6 weeks of high salt diet on α_1A-adrenoceptor regulation of renal tubular antinatriuretic and antidiuretic response in normal Wistar Kyoto rats.
To achieve the above objective, antinatriuretic and antidiuretic response to phenylephrine was measured in the absence and presence of 5-methylurapidil (5-MeU) using the inulin clearance method. Systemic mean arterial blood pressure and renal haemodynamics were also measured simultaneously.
Six weeks of high salt intake in Wistar-Kyoto (WKY) rats did not bring any significant increase in mean arterial blood pressure. WKY rat on high salt diet (WKYHNa) showed an exaggerated increase in absolute and fractional sodium excretion. There was a significant involvement of α_1A-adrenoceptor in carrying out renal tubular antinatriuretic and antidiuretic response in Wistar Kyoto rats on normal sodium diet (WKYNNa). However, α_1A-adrenoceptor played a minimal role in handling the tubular reabsorptive response in WKY rats on high salt diet.

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