血管内皮生长因子G1612A (rs10434)基因多态性与系统性红斑狼疮患者神经精神表现的关系

Revista Brasileira de Reumatologia (English Edition) Pub Date : 2017-03-01 DOI:10.1016/j.rbre.2016.11.007

Sherif Taha , Sherif Mohammed Gamal , Mohamed Nabil , Nahla Naeem , Dalia Labib , Ibrahim Siam , Tamer Atef Gheita

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引用次数: 5

摘要

目的探讨系统性红斑狼疮(SLE)患者血管内皮生长因子(VEGF)基因多态性与狼疮相关神经精神表现的关系。患者和方法从开罗大学附属医院的风湿病和神经内科招募60例成年SLE患者分为两组;A组:有神经精神症状(NPSLE)患者30例，B组:无神经精神症状患者30例。两组均采用实时聚合酶链反应(RT-PCR)对VEGF基因SNP G1612A (rs10434)进行基因分型。结果两组患者基因型及等位基因频率差异有统计学意义(AA [70%] vs . 13.3%， p <0.001]和GG [10% vs 66.7%， p <0.001])。结论VEGF基因编码多态性可能与SLE患者神经精神性狼疮发病率增高有关。

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Vascular endothelial growth factor G1612A (rs10434) gene polymorphism and neuropsychiatric manifestations in systemic lupus erythematosus patients

Aim

To investigate the relation between vascular endothelial growth factor (VEGF) gene polymorphism in systemic lupus erythematosus (SLE) patients and lupus related neuropsychiatric manifestations.

Patients and methods

Sixty adult SLE patients recruited from the Rheumatology and Neurology departments of Cairo University hospitals were classified into two groups; Group A: 30 patients with neuropsychiatric manifestations (NPSLE) and Group B: 30 patients without. For both groups the SNP G1612A (rs10434) of the VEGF gene was genotyped by real time polymerase chain reaction (RT-PCR).

Results

Statistically significant difference was found in genotype and allele frequencies between both groups (AA [70% vs 13.3%, p < 0.001] and GG [10% vs 66.7%, p < 0.001]).

Conclusion

Polymorphism in the gene coding for VEGF may be associated with increased incidence of neuropsychiatric lupus in SLE patients.

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Revista Brasileira de Reumatologia (English Edition)

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