牙周病、牙齿脱落和癌症风险。

IF 5.2 2区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Epidemiologic Reviews Pub Date : 2017-01-01 DOI:10.1093/epirev/mxx006
Dominique S Michaud, Zhuxuan Fu, Jian Shi, Mei Chung
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引用次数: 270

摘要

牙周病,包括牙龈炎和牙周炎,在成年人中非常普遍,疾病的严重程度随着年龄的增长而增加。牙周病和口腔癌之间的关系已经被研究了几十年,但人们对牙周病和整体癌症风险之间的联系越来越感兴趣,全身性炎症是生物学合理性的主要焦点。在过去的十年里,大量的病例对照研究已经研究了口腔健康在头颈癌中的作用,一些队列研究也研究了口腔健康与其他类型癌症的关系。在本综述中,我们纳入了从11篇关于该主题的已发表评论或PubMed上更新的文献检索(2011年至2016年7月)中确定的研究。本综述共纳入了来自46篇出版物的50项研究。当至少有4项研究可以纳入时,分别对队列研究和病例对照研究进行荟萃分析,以确定癌症风险与1)牙周病或2)牙齿数量(牙周病的替代标志物)相关的总结估计,并调整吸烟。现有数据支持牙周病与口腔癌、肺癌和胰腺癌风险呈正相关;然而,需要更多的前瞻性研究来更好地了解这些关联的强度,并确定其他癌症是否与牙周病有关。未来的研究应包括足够大的样本量,改进牙周病的测量方法,并彻底调整吸烟和其他危险因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Periodontal Disease, Tooth Loss, and Cancer Risk.

Periodontal disease, which includes gingivitis and periodontitis, is highly prevalent in adults and disease severity increases with age. The relationship between periodontal disease and oral cancer has been examined for several decades, but there is increasing interest in the link between periodontal disease and overall cancer risk, with systemic inflammation serving as the main focus for biological plausibility. Numerous case-control studies have addressed the role of oral health in head and neck cancer, and several cohort studies have examined associations with other types of cancers over the past decade. For this review, we included studies that were identified from either 11 published reviews on this topic or an updated literature search on PubMed (between 2011 and July 2016). A total of 50 studies from 46 publications were included in this review. Meta-analyses were conducted on cohort and case-control studies separately when at least 4 studies could be included to determine summary estimates of the risk of cancer in relation to 1) periodontal disease or 2) tooth number (a surrogate marker of periodontal disease) with adjustment for smoking. Existing data provide support for a positive association between periodontal disease and risk of oral, lung, and pancreatic cancers; however, additional prospective studies are needed to better inform on the strength of these associations and to determine whether other cancers are associated with periodontal disease. Future studies should include sufficiently large sample sizes, improved measurements for periodontal disease, and thorough adjustment for smoking and other risk factors.

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来源期刊
Epidemiologic Reviews
Epidemiologic Reviews 医学-公共卫生、环境卫生与职业卫生
CiteScore
8.10
自引率
0.00%
发文量
10
期刊介绍: Epidemiologic Reviews is a leading review journal in public health. Published once a year, issues collect review articles on a particular subject. Recent issues have focused on The Obesity Epidemic, Epidemiologic Research on Health Disparities, and Epidemiologic Approaches to Global Health.
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