构建中枢神经系统:揭示神经干细胞谱系。

Neurogenesis (Austin, Tex.) Pub Date : 2017-04-28 eCollection Date: 2017-01-01 DOI:10.1080/23262133.2017.1300037
Wenjun Xu, Nishanth Lakshman, Cindi M Morshead
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引用次数: 24

摘要

神经干细胞(NSCs)是哺乳动物中枢神经系统(CNS)心室周围区域的一种多能、自我更新的未分化细胞来源。自25年前首次发现以来,人们对它们的发展、持久性、局部化、性质和潜力有了很多了解。在此,我们讨论了目前关于神经干细胞的知识状况,重点关注沿神经轴的两个NSC群体及其在中枢神经系统中不同区域的生态位之间的谱系关系。
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Building a central nervous system: The neural stem cell lineage revealed.

Neural stem cells (NSCs) are a multipotent, self-renewing source of undifferentiated cells in the periventricular region of the mammalian central nervous system (CNS). Since their original discovery 25 years ago, much has been learned about their development, persistence, localization, properties and potential. Herein we discuss the current state of knowledge pertaining to neural stem cells with a focus on the lineage relationship between two NSC populations along the neuraxis and their regionally distinct niches in the CNS.

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