miR-145:胰腺癌中龙的复活

Journal of nature and science Pub Date : 2017-03-01
Saini Setua, Sheema Khan, Kyle Doxtater, Murali M Yallapu, Meena Jaggi, Subhash C Chauhan
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引用次数: 0

摘要

MicroRNA-145 (miR-145)在胰腺癌中作为肿瘤抑制因子的作用的出现,为新的治疗干预提供了潜力。我们最近发表的研究证明了miR-145在胰腺癌中的临床意义,并表明miR-145在人类胰腺肿瘤中的失调与致癌黏液蛋白MUC13的异常表达是平行的。这些研究还提出了一种新的治疗策略,通过纳米颗粒介导的有效递送系统恢复胰腺癌中miR-145的下调水平。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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miR-145: Revival of a Dragon in Pancreatic Cancer.

Emergence of the role of MicroRNA-145 (miR-145) as a tumor suppressor in pancreatic cancer, offers its potential for novel therapeutic interventions. Our recently published studies demonstrate clinical significance of miR-145 in pancreatic cancer and suggest that the dysregulation of miR-145 in human pancreatic tumors draws in parallel with the aberrant expression of an oncogenic mucin, MUC13. These studies also present a novel therapeutic strategy of restoring the downregulated levels of miR-145 in pancreatic cancer via nanoparticle mediated efficient delivery system.

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