Rinaldo Poncio Mendes, Ricardo de Souza Cavalcante, Sílvio Alencar Marques, Mariângela Esther Alencar Marques, James Venturini, Tatiane Fernanda Sylvestre, Anamaria Mello Miranda Paniago, Ana Carla Pereira, Julhiany de Fátima da Silva, Alexandre Todorovic Fabro, Sandra de Moraes Gimenes Bosco, Eduardo Bagagli, Rosane Christine Hahn, Adriele Dandara Levorato
{"title":"副球虫病：来自巴西的最新观点。","authors":"Rinaldo Poncio Mendes, Ricardo de Souza Cavalcante, Sílvio Alencar Marques, Mariângela Esther Alencar Marques, James Venturini, Tatiane Fernanda Sylvestre, Anamaria Mello Miranda Paniago, Ana Carla Pereira, Julhiany de Fátima da Silva, Alexandre Todorovic Fabro, Sandra de Moraes Gimenes Bosco, Eduardo Bagagli, Rosane Christine Hahn, Adriele Dandara Levorato","doi":"10.2174/1874285801711010224","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>This review article summarizes and updates the knowledge on paracoccidioidomycosis. <i>P lutzii</i> and the cryptic species of <i>P. brasiliensis</i> and their geographical distribution in Latin America, explaining the difficulties observed in the serological diagnosis.</p><p><strong>Objectives: </strong>Emphasis has been placed on some genetic factors as predisposing condition for paracoccidioidomycosis. Veterinary aspects were focused, showing the wide distribution of infection among animals. The cell-mediated immunity was better characterized, incorporating the recent findings.</p><p><strong>Methods: </strong>Serological methods for diagnosis were also compared for their parameters of accuracy, including the analysis of relapse.</p><p><strong>Results: </strong>Clinical forms have been better classified in order to include the pictures less frequently observesiod.</p><p><strong>Conclusion: </strong>Itraconazole and the trimethoprim-sulfamethoxazole combination was compared regarding efficacy, effectiveness and safety, demonstrating that azole should be the first choice in the treatment of paracoccidioidomycosis.</p>","PeriodicalId":38953,"journal":{"name":"Open Microbiology Journal","volume":"11 ","pages":"224-282"},"PeriodicalIF":0.0000,"publicationDate":"2017-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1874285801711010224","citationCount":"103","resultStr":"{\"title\":\"Paracoccidioidomycosis: Current Perspectives from Brazil.\",\"authors\":\"Rinaldo Poncio Mendes, Ricardo de Souza Cavalcante, Sílvio Alencar Marques, Mariângela Esther Alencar Marques, James Venturini, Tatiane Fernanda Sylvestre, Anamaria Mello Miranda Paniago, Ana Carla Pereira, Julhiany de Fátima da Silva, Alexandre Todorovic Fabro, Sandra de Moraes Gimenes Bosco, Eduardo Bagagli, Rosane Christine Hahn, Adriele Dandara Levorato\",\"doi\":\"10.2174/1874285801711010224\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>This review article summarizes and updates the knowledge on paracoccidioidomycosis. <i>P lutzii</i> and the cryptic species of <i>P. brasiliensis</i> and their geographical distribution in Latin America, explaining the difficulties observed in the serological diagnosis.</p><p><strong>Objectives: </strong>Emphasis has been placed on some genetic factors as predisposing condition for paracoccidioidomycosis. Veterinary aspects were focused, showing the wide distribution of infection among animals. The cell-mediated immunity was better characterized, incorporating the recent findings.</p><p><strong>Methods: </strong>Serological methods for diagnosis were also compared for their parameters of accuracy, including the analysis of relapse.</p><p><strong>Results: </strong>Clinical forms have been better classified in order to include the pictures less frequently observesiod.</p><p><strong>Conclusion: </strong>Itraconazole and the trimethoprim-sulfamethoxazole combination was compared regarding efficacy, effectiveness and safety, demonstrating that azole should be the first choice in the treatment of paracoccidioidomycosis.</p>\",\"PeriodicalId\":38953,\"journal\":{\"name\":\"Open Microbiology Journal\",\"volume\":\"11 \",\"pages\":\"224-282\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2017-10-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.2174/1874285801711010224\",\"citationCount\":\"103\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Open Microbiology Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2174/1874285801711010224\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2017/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q3\",\"JCRName\":\"Immunology and Microbiology\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Open Microbiology Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1874285801711010224","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2017/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"Immunology and Microbiology","Score":null,"Total":0}
Paracoccidioidomycosis: Current Perspectives from Brazil.
Background: This review article summarizes and updates the knowledge on paracoccidioidomycosis. P lutzii and the cryptic species of P. brasiliensis and their geographical distribution in Latin America, explaining the difficulties observed in the serological diagnosis.
Objectives: Emphasis has been placed on some genetic factors as predisposing condition for paracoccidioidomycosis. Veterinary aspects were focused, showing the wide distribution of infection among animals. The cell-mediated immunity was better characterized, incorporating the recent findings.
Methods: Serological methods for diagnosis were also compared for their parameters of accuracy, including the analysis of relapse.
Results: Clinical forms have been better classified in order to include the pictures less frequently observesiod.
Conclusion: Itraconazole and the trimethoprim-sulfamethoxazole combination was compared regarding efficacy, effectiveness and safety, demonstrating that azole should be the first choice in the treatment of paracoccidioidomycosis.
期刊介绍：
The Open Microbiology Journal is a peer-reviewed open access journal which publishes research articles, reviews/mini-reviews, case studies, guest edited thematic issues and short communications/letters covering theoretical and practical aspects of Microbial systematics, evolutionary microbiology, immunology, virology, parasitology , bacteriology, mycology, phycology, protozoology, microbial ecology, molecular biology, microbial physiology, biochemistry, microbial pathogenesis, host-microbe interaction, systems microbiology, synthetic microbiology, bioinformatics. The Open Microbiology Journal , a peer-reviewed journal, is an important and reliable source of current information on developments in the field. The emphasis will be on publishing quality papers rapidly and freely available to researchers worldwide.
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