鼻腔黏膜-纤毛运输时间的改变:18 B 甘草次酸的疗效。

IF 2.3 Multidisciplinary Respiratory Medicine Pub Date : 2017-11-29 eCollection Date: 2017-01-01 DOI:10.1186/s40248-017-0110-7
Desiderio Passali, Chiara Cappello, Giulio Cesare Passali, Cemal Cingi, Codrut Sarafoleanu, Luisa Maria Bellussi
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引用次数: 0

摘要

背景:粘液纤毛清除是鼻腔和副鼻窦的主要自我清除系统。这是一种非常重要的非特异性防御手段,可抵御空气中持续不断的有机和无机污染。它的工作原理是将颗粒和微生物截留在粘液中,然后将粘液膜输送到咽部,通过咳嗽或吞咽排出体外。它的先天或后天异常参与了广泛的感染性疾病的发生,通常是严重的鼻和鼻窦疾病;一般涉及鼻咽管区。本研究评估了吸入天然化合物(Narivent® 鼻喷雾剂)对慢性血管运动性鼻炎的临床疗效:研究涉及79名慢性血管运动性鼻炎患者,这些患者的粘液纤毛清除时间延长。第一组使用鼻腔喷雾剂(Narivent® 鼻腔喷雾剂)治疗(每个鼻孔喷 2 次,每天 2 次),为期 30 天;第二组使用含有等渗溶液的鼻腔喷雾剂治疗,方法和时间与第一组相同:研究结果表明,使用不溶性有色示踪剂(植物碳)的方法,其中一种治疗方法在客观上大大缩短了受检病人的黏膜纤毛清除时间,使数值恢复到正常范围内。研究结束时,我们发现97.9%的受试患者的粘液纤毛清除率有所提高:这项研究表明,在治疗慢性血管运动性鼻炎(一种以正常鼻黏膜形态和功能改变为特征的鼻腔炎症性疾病)时,使用具有恢复鼻黏膜功能的天然提取物治疗效果显著。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Nasal Muco-ciliary transport time alteration: efficacy of 18 B Glycyrrhetinic acid.

Background: Mucociliary clearance is the main self-clearing system of the nasal cavity and paranasal sinuses.This is a very important means of non specific defence against continuous organic and inorganic contamination conveyed by air. It works by trapping particles and microorganisms in the mucus and then by transporting the mucous film to the pharynx where it is eliminated with a cough or swallowed. Its congenital or acquired abnormalities are involved in the occurrence of widespread infectious and often severe nose and paranasal sinuses diseases; generally concerning the rhinopharyngealtubal district.Restoring mucociliary clearance of the nasal epithelium when altered thus represents a key therapeutic tool against rhinosinus chronic diseases.This study evaluates the clinical efficacy of the inhalation of a natural compound (Narivent® nasal spray) in chronic vasomotor rhinitis.

Methods: The study involved 79 patients suffering from chronic vasomotor rhinitis presenting an increased mucociliary clearance time. Patients were randomized into 2 groups: a first group of 49 subjects and a second group of 30 subjects.The first group was treated with a nasal spray (Narivent® nasal spray) (2 sprays per nostril twice a day) for 30 days.The second group was treated with a nasal spray containing isotonic solution in the same way and for the same period of the first group.Nasal Mucociliary transport time was measured in the patients of both groups before treatment, after 15 days of treatment, and at the end of the 30 days treatment.

Results: The study shows how one of the treatments carried out determines a major objective reduction of the mucociliary clearance time in the patients under examination, using the method which involves the use of an insoluble coloured tracer (vegetable carbon), bringing the values back within normal range. At the end of the study we objectivated an increase in the rate of mucociliary transport in 97.9% percentage of patients we enrolled.

Conclusions: This study shows the effectiveness of treatment with natural extracts with nasal mucosa restoring function in the treatment of chronic vasomotor rhinitis, a nasal inflammatory disease characterized by morphological and functional alteration of the normal nasal mucosa.

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来源期刊
Multidisciplinary Respiratory Medicine
Multidisciplinary Respiratory Medicine Medicine-Pulmonary and Respiratory Medicine
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0.00%
发文量
23
期刊介绍: Multidisciplinary Respiratory Medicine is the official journal of the Italian Respiratory Society - Società Italiana di Pneumologia (IRS/SIP). The journal publishes on all aspects of respiratory medicine and related fields, with a particular focus on interdisciplinary and translational research. The interdisciplinary nature of the journal provides a unique opportunity for researchers, clinicians and healthcare professionals across specialties to collaborate and exchange information. The journal provides a high visibility platform for the publication and dissemination of top quality original scientific articles, reviews and important position papers documenting clinical and experimental advances.
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