突发医学事件对ICU患者死亡率的影响

Luca Bonomi, Xiaoqian Jiang
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引用次数: 5

摘要

重症监护病房(icu)患者的研究是重症监护研究的一项重要任务,对确定临床危险因素和制定制度指导具有重要意义。ICU患者的死亡率研究特别有趣,因为它为医疗机构提供了有用的指征,以改善患者体验、内部政策和程序(例如资源分配)。为此,许多研究工作将ICU患者的住院时间(LOS)作为研究死亡率的一个特征。在这项工作中,我们提出了一种基于突发概念的新型死亡率研究,其中考虑了患者纵向数据的时间信息。在网络分析和时间序列异常检测中,时间数据的突发性是一种常用的度量方法,突发性的高值表明在短时间内存在快速发生的事件(即突发)。我们的直觉是,这些爆发可能与患者医疗状况中可能出现的并发症有关,因此提供了死亡率的指示。与LOS相比,突发参数捕获医疗事件的时间性,提供有关患者状况整体动态的信息。据我们所知,我们是第一个在临床研究领域应用爆发性测量的公司。我们在真实数据集上的初步结果表明,与更常规的医疗事件相比,高爆发值的患者往往具有更高的死亡率。总的来说,我们的研究显示了有希望的结果,并为开发时间数据的预测模型和推进现代危重病医学提供了有用的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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A Mortality Study for ICU Patients using Bursty Medical Events.

The study of patients in Intensive Care Units (ICUs) is a crucial task in critical care research which has significant implications both in identifying clinical risk factors and defining institutional guidances. The mortality study of ICU patients is of particular interest because it provides useful indications to healthcare institutions for improving patients experience, internal policies, and procedures (e.g. allocation of resources). To this end, many research works have been focused on the length of stay (LOS) for ICU patients as a feature for studying the mortality. In this work, we propose a novel mortality study based on the notion of burstiness, where the temporal information of patients longitudinal data is taken into consideration. The burstiness of temporal data is a popular measure in network analysis and time-series anomaly detection, where high values of burstiness indicate presence of rapidly occurring events in short time periods (i.e. burst). Our intuition is that these bursts may relate to possible complications in the patient's medical condition and hence provide indications on the mortality. Compared to the LOS, the burstiness parameter captures the temporality of the medical events providing information about the overall dynamic of the patients condition. To the best of our knowledge, we are the first to apply the burstiness measure in the clinical research domain. Our preliminary results on a real dataset show that patients with high values of burstiness tend to have higher mortality rate compared to patients with more regular medical events. Overall, our study shows promising results and provides useful insights for developing predictive models on temporal data and advancing modern critical care medicine.

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