Iraklis Vastardis, Brigitte Pajic-Eggspuehler, Charis Nichorlis, Jörg Mueller, Bojan Pajic
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引用次数: 10
摘要
背景:Seiler等人提出的与uv - a (UVA)和核黄素光敏剂(Vit B2)的角膜交联(CXL)，彻底改变了圆锥角膜和其他角膜扩张性疾病的治疗。今天，众所周知的德累斯顿上皮方案在过去15年的临床应用中取得了巨大的成功，并被许多人视为黄金标准。方法:该方法简便、有效、安全，为角膜膨胀性疾病的治疗开辟了新方法和新策略，改变了我们对角膜生物力学的认识。最近的科学和技术进步使对最初的CXL协议进行各种修改和形成新的协议成为可能。结论:本文重点介绍了CXL的最新进展，如氧的作用、更高的通量和更短的照射时间，以及该方法的各种临床应用和更新。
Recent Innovations in Collagen Corneal Cross-linking; a Mini Review.
Background: The introduction of corneal cross-linking (CXL) with ultraviolet-A (UVA) and Riboflavin photosensitizer (Vit B2) from Seiler et al., revolutionized the treatment of Keratoconus and other corneal ectatic diseases. Today, the commonly known epithelium off Dresden protocol is in clinical use for the last 15 years with great success and regarded by many as the golden standard.
Methods: With several studies demonstrating its simplicity, efficacy and safety this revolutionary method, paved the way for new therapies and strategies in the treatment of corneal ectatic diseases and changed our understanding in corneal biomechanics. Recent scientific and technological advances enabled the creation of various modifications of the initial CXL protocol and the formation of new ones.
Conclusion: This work highlights the recent advances of CXL, such as the role of oxygen, higher fluence and shorter irradiation times as well as the various clinical applications and updates of this method.
期刊介绍：
The Open Ophthalmology Journal is an Open Access online journal, which publishes research articles, reviews/mini-reviews, letters and guest edited single topic issues in all important areas of experimental and clinical research in ophthalmology, including use of ophthalmological therapies, devices and surgical techniques. The Open Ophthalmology Journal, a peer-reviewed journal, is an important and reliable source of current information on developments in the field. The emphasis will be on publishing quality papers rapidly and making them freely available to researchers worldwide.
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