Mohammad Al-Masum, Linda Quinones, Laurance T Cain
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Microwave Application and Anhydrous Cu(OAc)2 Mediated O-Arylation of Aliphatic Amino Alcohols.
Anhydrous Cu(OAc)2 mediated efficient protocol has been developed in the area of C-O coupling from potassium aryltrifluoroborates and aliphatic amino alcohols such as β-hydroxy, γ-hydroxy, and δ-hydroxy amines. The scope of this transformation focuses on direct O-arylation and Ostyrylation. The reaction vial loaded with reactants under argon atmosphere is microwaved at 140°C for 30 min to furnish the corresponding cross-coupling product, amino ethers, in good yields.
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