生物技术治疗在风湿病中的抗血管生成作用。

IF 5.3 Q1 MEDICINE, RESEARCH & EXPERIMENTAL Biologics : Targets & Therapy Pub Date : 2017-12-14 eCollection Date: 2017-01-01 DOI:10.2147/BTT.S143674

Francesco Paolo Cantatore, Nicola Maruotti, Addolorata Corrado, Domenico Ribatti

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引用次数: 10

摘要

血管生成在许多风湿性疾病的发病机制中起着关键作用，如类风湿关节炎、银屑病关节炎和血管管炎。因此，抑制病理性血管生成可能被认为是治疗这些风湿性疾病的有效方法。方法:在文献综述的基础上，对生物技术治疗在血管生成抑制中的作用进行综述。结果与结论:多项证据表明生物技术治疗在血管生成抑制中具有重要作用。然而，需要进一步的研究和临床试验来更好地量化生物技术治疗对病理性血管生成的真正影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Anti-angiogenic effects of biotechnological therapies in rheumatic diseases.

Introduction: Angiogenesis plays a key role in the pathogenesis of numerous rheumatic diseases, such as rheumatoid arthritis, psoriatic arthritis, and vasculitides. Therefore, the inhibition of pathological angiogenesis may be considered a useful therapeutical approach in these rheumatic diseases.

Methods: This review article is based on a literature research about the role of biotechnological therapies in angiogenesis inhibition.

Results and conclusions: Several evidences have demonstrated a role for biotechnological therapies in angiogenesis inhibition. Nevertheless, further research and clinical trials are needed to better quantify the real impact of biotechnological therapies on pathological angiogenesis.

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