Basiru O Ajiboye, Oluwafemi A Ojo, Oluwatosin Adeyonu, Oluwatosin D Imiere, Adewale O Fadaka, Adetutu O Osukoya
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Ameliorative Activity of Ethanol Extract of Artocarpus heterophyllus Stem Bark on Pancreatic β-Cell Dysfunction in Alloxan-Induced Diabetic Rats.
This study sought to investigate the ameliorative effects of ethanol extract Artocarpus heterophyllus (EAH) in alloxan-induced diabetic rats. The rats were divided into 6 groups, with groups 1 and 2 serving as nondiabetic and diabetic control, respectively; group 3 serving as diabetic rats treated with 5 mg/kg glibenclamide; and groups 4 to 6 were diabetic rats treated with 50, 100, and 150 mg/kg of EAH, respectively. Assays determined were serum insulin, lipid peroxidation, and antioxidant enzyme activities. EAH stem bark reduced fasting blood glucose and lipid peroxidation levels and increased serum insulin levels and activities of antioxidant enzymes. Data obtained demonstrated the ability of EAH stem bark to ameliorate pancreatic β-cell dysfunction in alloxan-induced diabetic rats.
期刊介绍：
The Journal of Evidence-Based Integrative Medicine ((JEBIM)), published previously as the Journal of Evidence-Based Complementary and Alternative Medicine (JEBCAM) and also as Complementary Health Practice Review (CHPR). The Journal of Evidence-Based Integrative Medicine (JEBIM) is an interdisciplinary, peer-reviewed, open access, biomedical journal whose aim is to create a global platform for hypothesis-driven and evidence-based research in all fields of integrative medicine. The journal’s objective is to publish papers which impart scientific validity to Integrative Medicine methods that are indispensable and inevitable in today’s world. All papers will be peer reviewed by experts in their respective fields, and papers will be accepted based on their scientific merit. It is the goal of the Journal to help remove the “myth” and provide scientific rationale for the various methodologies and theories of Integrative Medicine. All submissions will be reviewed based on their scientific merit and only papers with sound study design, valid statistical analyses and logical conclusions will be accepted. Topics include, but are not limited to: Traditional Eastern and Western medicine Nutrition therapy and supplementation Massage Therapy Non-traditional treatments Preventative medicine Integrative health and medicine Mindfulness Yoga.
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