c-Jun n -末端激酶-3磷酸化纯化线粒体电压依赖性阴离子通道修饰通道电压依赖性

Rajeev Gupta , Subhendu Ghosh
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引用次数: 12

摘要

由c-Jun n -末端激酶-3 (JNK3)磷酸化的电压依赖性阴离子通道(VDAC)被纳入双层脂质膜。比较了天然VDAC和磷酸化VDAC的单通道电生理特性。天然VDAC的打开概率随电压曲线沿电压轴呈对称性,而磷酸化VDAC的打开概率随电压轴呈不对称性。这一结果表明JNK3的磷酸化修饰了VDAC的电压依赖性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Phosphorylation of purified mitochondrial Voltage-Dependent Anion Channel by c-Jun N-terminal Kinase-3 modifies channel voltage-dependence

Voltage-Dependent Anion Channel (VDAC) phosphorylated by c-Jun N-terminal Kinase-3 (JNK3) was incorporated into the bilayer lipid membrane. Single-channel electrophysiological properties of the native and the phosphorylated VDAC were compared. The open probability versus voltage curve of the native VDAC displayed symmetry around the voltage axis, whereas that of the phosphorylated VDAC showed asymmetry. This result indicates that phosphorylation by JNK3 modifies voltage-dependence of VDAC.

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