自杀企图史与精神分裂症患者情绪决策时内侧前额叶皮层活动减少有关:一项探索性功能磁共振成像研究

IF 3.6 Q1 PSYCHIATRY Schizophrenia Research and Treatment Pub Date : 2018-03-01 eCollection Date: 2018-01-01 DOI:10.1155/2018/9898654
Stéphane Potvin, Andràs Tikàsz, Stéphane Richard-Devantoy, Ovidiu Lungu, Alexandre Dumais
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引用次数: 19

摘要

尽管精神分裂症患者有很高的自杀念头/企图,但只有少数神经影像学研究调查了这一人群中与自杀风险相关的神经生物学差异。当前探索性研究的主要目的是通过高风险的决策任务,检查与精神分裂症患者自杀企图史相关的神经功能,以显示该人群大脑奖励区域的变化。本研究招募了32例精神分裂症门诊男性患者:13例(SCZ + S)患者和19例(SCZ - S)患者。21例健康男性,无精神障碍史或自杀企图/念头。参与者在执行气球模拟风险任务时使用功能磁共振成像进行扫描。采用快速事件相关fMRI范式,分离决策事件和结果事件,并将爆炸概率作为参数调制器。本研究最重要的发现是,与SCZ - S患者和对照组相比,SCZ + S患者在成功结果事件(参数调制)期间内侧前额叶皮层的激活减少,这一点通过空间关联分析得到了证明。这些探索性结果表明,精神分裂症患者的自杀企图史与情绪决策过程中大脑奖励活动减弱有关。
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History of Suicide Attempt Is Associated with Reduced Medial Prefrontal Cortex Activity during Emotional Decision-Making among Men with Schizophrenia: An Exploratory fMRI Study.

Despite the high prevalence of suicidal ideas/attempts in schizophrenia, only a handful of neuroimaging studies have examined the neurobiological differences associated with suicide risk in this population. The main objective of the current exploratory study is to examine the neurofunctional correlates associated with a history of suicide attempt in schizophrenia, using a risky decision-making task, in order to show alterations in brain reward regions in this population. Thirty-two male outpatients with schizophrenia were recruited: 13 patients with (SCZ + S) and 19 without a history of suicidal attempt (SCZ - S). Twenty-one healthy men with no history of mental disorders or suicidal attempt/idea were also recruited. Participants were scanned using fMRI while performing the Balloon Analogue Risk Task. A rapid event-related fMRI paradigm was used, separating decision and outcome events, and the explosion probabilities were included as parametric modulators. The most important finding of this study is that SCZ + S patients had reduced activations of the medial prefrontal cortex during the success outcome event (with parametric modulation), relative to both SCZ - S patients and controls, as illustrated by a spatial conjunction analysis. These exploratory results suggest that a history of suicidal attempt in schizophrenia is associated with blunted brain reward activity during emotional decision-making.

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来源期刊
CiteScore
4.60
自引率
0.00%
发文量
2
审稿时长
14 weeks
期刊介绍: Schizophrenia Research and Treatment is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to all aspects of schizophrenia.
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