美托咪定、咪达唑仑和布托啡诺混合麻醉剂在棉大鼠中的应用。

IF 0.4 4区 农林科学 Q4 VETERINARY SCIENCES Japanese Journal of Veterinary Research Pub Date : 2016-11-01
Teppei Nakamura, Osamu Ichii, Takao Irie, Marina Hosotani, Ai Dantsuka, Saori Nakamura, Shinobu Sato, Kozue Sotozaki, Hirokazu Kouguchi, Tomoji Yoshiyasu, Ken-Ichi Nagasaki, Yasuhiro Kon
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引用次数: 0

摘要

棉鼠(Sigmodon hispidus)是一种用于研究人类传染病的实验室啮齿动物。然而,由于缺乏合适的麻醉剂,棉鼠在手术操作中的使用不便。本研究表明,美托咪定、咪达唑仑和布托啡诺的混合物(分别为0.15、2.0和2.5 mg/kg)是一种适用于小鼠和大鼠的麻醉剂,皮下注射对棉花大鼠的麻醉持续时间超过50 min。我们还证明,0.15 mg/kg的阿替帕唑(美托咪定的拮抗剂)能使棉花大鼠从麻醉中迅速恢复。这表明美托咪定、咪达唑仑和布托啡诺的混合麻醉对棉花大鼠的短期手术是一种有效的麻醉剂。
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Usefulness of an anesthetic mixture of medetomidine, midazolam, and butorphanol in cotton rats (Sigmodn hispidus).

Tne cotton rat (Sigmodon hispidus) is a laboratory rodent used for studying human infectious diseases. However, a lack of suitable anesthetic agents inconveniences the use of cotton rats in surgical manipulation. This study demonstrated that subcutaneous injection of the mixture of medetomidine, midazolam, and butorphanol (0.15, 2.0, and 2.5 mg/kg, respectively), which is a suitable anesthetic agents for mice and rats, produced an anesthetic duration of more than 50 min in cotton rats. We also demonstrated that 0.15 mg/kg of atipamezole, an antagonist of medetomidine, produced a quick recovery from anesthesia in cotton rats. This indicated that the anesthetic mixture of medetomidine, midazolam, and butorphanol, functioned as a useful and effective anesthetic for short-term surgery in cotton rats.

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来源期刊
CiteScore
1.00
自引率
0.00%
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0
审稿时长
>36 weeks
期刊介绍: The Japanese Journal of Veterinary Research (JJVR) quarterly publishes peer-reviewed articles on all aspects of veterinary science. JJVR was originally published as a “University Journal” of veterinary science at Hokkaido University from more than 60 years ago. Currently, JJVR, is Japan’s leading scientific veterinary journal, and provides valuable information for the development of veterinary science by welcoming contributions from researchers worldwide. JJVR offers online submission for Regular Papers, Short Communications, and Review Articles that are unpublished and not being considered for publication elsewhere. Research areas include: Anatomy, Physiology, Biochemistry, Pharmacology, Microbiology, Infectious diseases, Parasitology, Laboratory Animal Science and Medicine, Internal Medicine, Surgery, Pathology, Theriogenology, Molecular Medicine, Public Health, Radiation Biology, Toxicology, Wildlife Biology and Medicine, Veterinary Hygiene, The other fields related to veterinary science.
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