{"title":"2-氨基乙磺酸镁对对乙酰氨基酚和乙醇致妊娠大鼠肝损伤的保护作用。","authors":"E V Blinova, M A Halzova, D S Blinov","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The goal: to investigate a preventive activity for novel medication magnesium 2-aminoethansulfonate in experimental hepatitis in pregnant rats.</p><p><strong>Material and methods: </strong>The study has been conducted in firs week pregnant rats with paracetamol and ethanol-induced liver injury.</p><p><strong>Results: </strong>There has been found out that new domestic compound magnesium 2-aminoethansulfonate (laboratory name LBK-527) introduced daily at a dose of 28 mg/kg per os during 6 days, limits cytolysis and cholestasis caused by either paracetamol or ethanol intake in experiments in pregnant rats. Study shows that liver of the animals, that have been given LBK-527 simultaneously with either 500 mg/kg paracetamol or 10 ml/kg 40% ethanol, remains being structurally close to normal. The substance prevents acute toxic liver dystrophy and the organ's structure disintegration made by mentioned toxic agents. Having administered at a therapeutic dose LBK-527 isn't associated with faetotoxicity and embriototoxity in experiments in rats.</p>","PeriodicalId":11555,"journal":{"name":"Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology","volume":" 10","pages":"50-53"},"PeriodicalIF":0.0000,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A PROTECTIVE ROLE FOR MAGNESIUM 2-AMINOETHANSULFONATE IN PARACETAMOL AND ETHANOL-INDUCED LIVER INJURY IN PREGNANT RATS.\",\"authors\":\"E V Blinova, M A Halzova, D S Blinov\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The goal: to investigate a preventive activity for novel medication magnesium 2-aminoethansulfonate in experimental hepatitis in pregnant rats.</p><p><strong>Material and methods: </strong>The study has been conducted in firs week pregnant rats with paracetamol and ethanol-induced liver injury.</p><p><strong>Results: </strong>There has been found out that new domestic compound magnesium 2-aminoethansulfonate (laboratory name LBK-527) introduced daily at a dose of 28 mg/kg per os during 6 days, limits cytolysis and cholestasis caused by either paracetamol or ethanol intake in experiments in pregnant rats. Study shows that liver of the animals, that have been given LBK-527 simultaneously with either 500 mg/kg paracetamol or 10 ml/kg 40% ethanol, remains being structurally close to normal. The substance prevents acute toxic liver dystrophy and the organ's structure disintegration made by mentioned toxic agents. Having administered at a therapeutic dose LBK-527 isn't associated with faetotoxicity and embriototoxity in experiments in rats.</p>\",\"PeriodicalId\":11555,\"journal\":{\"name\":\"Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology\",\"volume\":\" 10\",\"pages\":\"50-53\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2016-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
A PROTECTIVE ROLE FOR MAGNESIUM 2-AMINOETHANSULFONATE IN PARACETAMOL AND ETHANOL-INDUCED LIVER INJURY IN PREGNANT RATS.
The goal: to investigate a preventive activity for novel medication magnesium 2-aminoethansulfonate in experimental hepatitis in pregnant rats.
Material and methods: The study has been conducted in firs week pregnant rats with paracetamol and ethanol-induced liver injury.
Results: There has been found out that new domestic compound magnesium 2-aminoethansulfonate (laboratory name LBK-527) introduced daily at a dose of 28 mg/kg per os during 6 days, limits cytolysis and cholestasis caused by either paracetamol or ethanol intake in experiments in pregnant rats. Study shows that liver of the animals, that have been given LBK-527 simultaneously with either 500 mg/kg paracetamol or 10 ml/kg 40% ethanol, remains being structurally close to normal. The substance prevents acute toxic liver dystrophy and the organ's structure disintegration made by mentioned toxic agents. Having administered at a therapeutic dose LBK-527 isn't associated with faetotoxicity and embriototoxity in experiments in rats.
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