药物检测用微流体装置。

Q2 Biochemistry, Genetics and Molecular Biology High-Throughput Pub Date : 2018-06-20 DOI:10.3390/ht7020018

Clément Regnault, Dharmendra S Dheeman, Axel Hochstetter

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引用次数: 42

摘要

在这篇综述中，我们概述了基于微流体的高通量药物分析的现状。在这个高度跨学科的研究领域，各种方法已被应用于高通量药物筛选，包括微量滴定板、液滴微流体以及基于连续流动、扩散和浓度梯度的微流体药物分析。因此，我们回顾了该领域最近的100多篇出版物，并根据它们的微流体方法对它们进行了分类。因此，我们正在展示、比较和讨论广泛应用的方法，以及可能有助于塑造该领域未来的独特有前途的方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Microfluidic Devices for Drug Assays.

In this review, we give an overview of the current state of microfluidic-based high-throughput drug assays. In this highly interdisciplinary research field, various approaches have been applied to high-throughput drug screening, including microtiter plate, droplets microfluidics as well as continuous flow, diffusion and concentration gradients-based microfluidic drug assays. Therefore, we reviewed over 100 recent publications in the field and sorted them according to their microfluidic approach. As a result, we are showcasing, comparing and discussing broadly applied approaches as well as singular promising ones that might contribute to shaping the future of this field.

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来源期刊

High-Throughput Biochemistry, Genetics and Molecular Biology-Biotechnology

CiteScore

3.60

自引率

0.00%

发文量

审稿时长

9 weeks

期刊介绍： High-Throughput (formerly Microarrays, ISSN 2076-3905) is a multidisciplinary peer-reviewed scientific journal that provides an advanced forum for the publication of studies reporting high-dimensional approaches and developments in Life Sciences, Chemistry and related fields. Our aim is to encourage scientists to publish their experimental and theoretical results based on high-throughput techniques as well as computational and statistical tools for data analysis and interpretation. The full experimental or methodological details must be provided so that the results can be reproduced. There is no restriction on the length of the papers. High-Throughput invites submissions covering several topics, including, but not limited to: -Microarrays -DNA Sequencing -RNA Sequencing -Protein Identification and Quantification -Cell-based Approaches -Omics Technologies -Imaging -Bioinformatics -Computational Biology/Chemistry -Statistics -Integrative Omics -Drug Discovery and Development -Microfluidics -Lab-on-a-chip -Data Mining -Databases -Multiplex Assays