姜黄素在调节TNF-α介导的脑炎症反应中的作用。

IF 4.2 Q3 Pharmacology, Toxicology and Pharmaceutics Recent patents on inflammation & allergy drug discovery Pub Date : 2018-01-01 DOI:10.2174/1872213X12666180703163824
Tirthraj Baj, Rohit Seth
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引用次数: 29

摘要

背景:炎症是身体系统的一种保护性反应,保护身体免受各种外部和内部的伤害;然而,已经发现大多数慢性疾病是由失调和过度炎症引起的。炎症在神经系统疾病中起着重要作用。在脑细胞因子中,TNF-α和TNF-β在许多疾病中介导炎症。这些细胞因子的功能受转录因子NF-κb的激活调控。最近的证据表明,姜黄素具有巨大的治疗潜力,因为它具有抗炎和抗氧化的特性。它已经被测试用于治疗各种与大脑有关的慢性疾病。目的:研究姜黄素在缓解TNF-α和NF-κb信号引发的炎症反应中的作用。方法:本研究是对PubMed central、science direct、medline和现有科学数据库等来源的文献进行调查,以确定炎症在神经退行性疾病的发展中如何发挥重要作用以及姜黄素作为抗炎剂的作用。研究姜黄素在减轻炎症反应中的重要性,本文引用了一些专利申请和接受。结果:TNF-α介导的神经炎症在阿尔茨海默病、帕金森病、多发性硬化症、肌萎缩侧索硬化症等疾病的发生发展中起重要作用。姜黄素似乎可以平息或减少炎症反应。因此,它似乎具有治疗各种神经炎症性疾病的治疗潜力。结论:细胞因子在神经退行性疾病中上调,导致大脑炎症反应的启动。据报道,姜黄素具有抗炎特性,因此补充姜黄素可能有助于减轻炎症。未来在这方面的研究将进一步阐明姜黄素减轻神经炎症的作用机制。
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Role of Curcumin in Regulation of TNF-α Mediated Brain Inflammatory Responses.

Background: Inflammation is a protective response of the body system that protects the body from the various kinds of external and internal insults; however, it has been found that most chronic illnesses are caused by dysregulated and excessive inflammation. Inflammation plays a major role in developing neurological diseases. In the brain cytokines, TNF-α and TNF-β are known to mediate inflammation in many diseases. Functions of these cytokines are regulated by the activation of transcription factor NF-κb. Recent evidence suggest that curcumin has an immense therapeutic potential because of its anti-inflammatory and anti-oxidant properties. It has been tested for treating various chronic illnesses associated with the brain.

Objective: The study aims to elucidate the role of curcumin in alleviating the inflammatory reactions initiated by TNF-α and NF-κb signaling.

Methods: This study is a survey of literature from sources like PubMed central, science direct, medline and available scientific databases to determine how inflammation plays an important role in the development of neurodegenerative diseases and the role of curcumin as an anti-inflammatory agent. Looking into the importance of curcumin in alleviating inflammatory responses, several patents are filed and accepted which are referenced in this article.

Results: Neuro-inflammation mediated by TNF-α plays a major role in the development of pathologies like Alzheimer's disease, Parkinson's disease, multiple sclerosis, amyotrophic lateral sclerosis etc. Curcumin appears to subside or reduce the inflammatory responses. Thus, it appears to have therapeutic potential for treating various neuroinflammatory diseases.

Conclusion: Cytokines get upregulated during neurodegenerative diseases as a result of which inflammatory responses are initiated in the brain. Curcumin is reported to have anti-inflammatory properties and thereby its supplementation may help in reducing the inflammation. Future research on this area will further explain the mode of action of curcumin in alleviating neuroinflammation.

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期刊介绍: Recent Patents on Inflammation & Allergy Drug Discovery publishes review articles by experts on recent patents in the field of inflammation and allergy drug discovery e.g. on novel bioactive compounds, analogs and targets. A selection of important and recent patents in the field is also included in the journal. The journal is essential reading for all researchers involved in inflammation and allergy drug design and discovery.
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Meet Our Editorial Board Member Diagnosis of Allergic Reactions to Drugs Non-steroidal Anti-inflammatory Drugs Other Antimicrobial Drugs Biologics: Monoclonal Antibodies for Non-cancer Therapy, Cytokines, Fusion Proteins, Enzymes, and Hormones
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