[EFFECT OF NMDA-RECEPTOR BLOCKERS ON THE DYNAMICS OF INTRAOCULAR PRESSURE IN RABBITS].

Experiments on rabbits with a model of acute temporary ocular hypertension created by intragastric administration of water (100 ml/kg) have been performed. It was found that intravenous administration or instillation into the eye of blocker of NMDA-receptor 1-adamantylethyloxy-3-morpholino-2- propanol hydrochloride (Ademol) unlike amantadine sulfate results in a significant decrease in intraocular pressure (IOP). It was also discovered that such ocular hypotensive effect takes place in animals with unchanged ophthalmotonus. Taking into account neuroretinoprotective and hypotensive ocular hypotensive properties of Ademol this drug appears to be perspective in the treatment of ischemic disorders of the retina and optic nerve, especially under the conditions of increased IOP.