Yan Yan, Qiang Li, Chen-hui Du, Jin-ping Jia, Hong-xia Feng, Xue-mei Qin
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[Investigation of the potentially effective components of Semen Ziziphi Spinosae based on “in vitro to in vivo” translation approach].
The study aims to investigate the effective components of Semen Ziziphi Spinosae (SZR) in
nourishing the heart and tranquilizing the mind. A method of ultra high liquid chromatography (UHPLC)
coupled with Q Exactive high resolution mass spectrometry (HR-MS) was developed. Based on the UV spectra,
retention time and MS spectra, 25 compounds of SZR extract were identified or tentatively characterized,
including 12 flavonoids, 8 triterpenoids saponins, 2 fatty acid and 3 alakoids. The study illuminated the major
chemical components. Twenty bioactive components were determined in rat urine after oral administration of
SZR extract by “in vitro to in vivo” translation approach, including 16 prototype compounds and 4 metabolites.
Spinosin, swertisin, jujuboside A and B were considered as the effective and active constituents in SZR of
the sedative and hypnotic effects, which emodies characteristics of multiple components. It was beneficial
exploration for searching the effective and active constituents of SZR in nourishing the heart and tranquilizing
the mind.
药学学报Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)
CiteScore
1.20
自引率
0.00%
发文量
0
期刊介绍：
Acta Pharmaceutica Sinica B (APSB) is a bimonthly English peer-reviewed online journal in ScienceDirect, which publishes significant original research articles, communications and high quality reviews of recent advances. APSB encourages submissions from all areas of pharmaceutical sciences, including pharmacology, pharmaceutics, medicinal chemistry, natural products, pharmacognosy, pharmaceutical analysis and pharmacokinetics.
APSB is a part of the series Acta Pharmaceutica Sinica, which was founded in 1953. The journal is co-published by Elsevier B.V., in association with the Institute of MateriaMedica, Chinese Academy of Medical Sciences and Chinese Pharmaceutical Association.
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