CD40-CD40L轴在抗感染和癌症免疫中的多重作用。

IF 6.2 Q1 IMMUNOLOGY ImmunoTargets and Therapy Pub Date : 2018-06-28 eCollection Date: 2018-01-01 DOI:10.2147/ITT.S163614

Anjuman Ara, Khawaja Ashfaque Ahmed, Jim Xiang

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引用次数: 42

摘要

CD8+细胞毒性T淋巴细胞(CTL)可以抵抗感染和癌细胞。了解产生和维持有效CTL反应的机制对于改善疾病治疗和疫苗方案至关重要。在CTL反应过程中，免疫细胞会遇到几种受到严格调控的信号通路;因此，在这样一个动态的过程中，适当整合关键信号是必要的，以协调有效的免疫反应。在这篇综述中，我们主要关注CD40-CD40L相互作用(一个关键信号)在调节树突状细胞(DC)-T细胞(CD4+ T和CD8+ T)串音、挽救CTL衰竭和转换DC耐受中的作用。我们还强调了知识差距和未来设计免疫疗法的方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Multiple effects of CD40-CD40L axis in immunity against infection and cancer.

CD8⁺ cytotoxic T lymphocyte (CTL) protects against infection and cancer cells. Understanding the mechanisms involved in generation and maintenance of effective CTL responses is essential for improving disease therapy and vaccine protocols. During CTL responses, immune cells encounter several tightly regulated signaling pathways; therefore, in such a dynamic process, proper integration of critical signals is necessary to orchestrate an effective immune response. In this review, we have focused on CD40-CD40L interactions (a key signal) in the regulation of dendritic cell (DC)-T cell (CD4⁺ T and CD8⁺ T) cross-talk, rescuing CTL exhaustion, and converting DC tolerization. We have also highlighted the knowledge gap and future directions to design immunotherapies.

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来源期刊

ImmunoTargets and Therapy IMMUNOLOGY-

CiteScore

16.50

自引率

0.00%

发文量

审稿时长

16 weeks

期刊介绍： Immuno Targets and Therapy is an international, peer-reviewed open access journal focusing on the immunological basis of diseases, potential targets for immune based therapy and treatment protocols employed to improve patient management. Basic immunology and physiology of the immune system in health, and disease will be also covered.In addition, the journal will focus on the impact of management programs and new therapeutic agents and protocols on patient perspectives such as quality of life, adherence and satisfaction.