原发性进行性失语症的语言学方面。

IF 3 1区 文学 0 LANGUAGE & LINGUISTICS Annual Review of Linguistics Pub Date : 2018-01-01 Epub Date: 2017-10-20 DOI:10.1146/annurev-linguistics-011516-034253
Murray Grossman
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引用次数: 0

摘要

原发性进行性失语症(PPA)是指一种与神经退行性疾病(如额颞叶变性和阿尔茨海默病)相关的语言衰退性疾病。从医学角度来看,认识 PPA 的变异非常重要,因为这些综合征是提示特定潜在病理的临床标记。在这篇综述中,我将讨论 PPA 综合征的语言学方面,这些方面可能会为解析我们的语言机制和识别语言基本要素的神经表征提供信息。我重点讨论了语义变异型 PPA 中的词义表征、非流利/语法变异型 PPA 中的语法理解和表达、对数变异型 PPA 中的短时记忆的支持作用,以及行为变异型额颞叶痴呆症中与话语相关的语言成分。PPA 提供了一个新的视角,独特地探讨了语言及其障碍的各个方面,同时补充了中风后的传统失语综合症。
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Linguistic Aspects of Primary Progressive Aphasia.

Primary progressive aphasia (PPA) refers to a disorder of declining language associated with neurodegenerative diseases such as frontotemporal degeneration and Alzheimer disease. Variants of PPA are important to recognize from a medical perspective because these syndromes are clinical markers suggesting specific underlying pathology. In this review, I discuss linguistic aspects of PPA syndromes that may prove informative for parsing our language mechanism and identifying the neural representation of fundamental elements of language. I focus on the representation of word meaning in a discussion of semantic variant PPA, grammatical comprehension and expression in a discussion of nonfluent/agrammatic variant PPA, the supporting role of short-term memory in a discussion of logopenic variant PPA, and components of language associated with discourse in a discussion of behavioral variant frontotemporal dementia. PPA provides a novel perspective that uniquely addresses facets of language and its disorders while complementing traditional aphasia syndromes that follow stroke.

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来源期刊
CiteScore
7.20
自引率
6.20%
发文量
37
期刊介绍: The Annual Review of Linguistics, in publication since 2015, covers significant developments in the field of linguistics, including phonetics, phonology, morphology, syntax, semantics, pragmatics, and their interfaces. Reviews synthesize advances in linguistic theory, sociolinguistics, psycholinguistics, neurolinguistics, language change, biology and evolution of language, typology, as well as applications of linguistics in many domains.
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