Jinglin An , Xue Zhou , Yifan Zhang , Zhenfei Ye , Qianyou Guo , Hao Song , Zhenlei Song , Xiao-Yu Liu , Yong Qin
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Carboxylic acid-assisted sterically demanding reductive cross-coupling between cycloalkenyl and alkyl bromides†
A nickel-catalysed reductive cross-coupling reaction between 2-bromo cycloalkenyl carboxylic acids and alkyl bromides has been developed, affording all-carbon tetrasubstituted cycloalkenes in moderate to excellent yields up to 92%. Mechanistic studies indicated that the carboxylic acid group plays an important assisting role in this sterically demanding coupling reaction.
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