化疗在黑色素瘤现代治疗中的作用。

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2017-05-01 Epub Date: 2017-05-19 DOI:10.2217/mmt-2017-0003

Avinash Gupta, Fabio Gomes, Paul Lorigan

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引用次数: 0

摘要

恶性黑色素瘤的治疗在过去的7年里发生了翻天覆地的变化。以前单剂达卡巴嗪通常是治疗晚期疾病的唯一药物，现在有可能基于免疫疗法和靶向治疗选择的多种治疗方法，可以是单药治疗，也可以是联合治疗。在这个勇敢的新世界里，问题来了，化疗在黑色素瘤的现代治疗中还有意义吗？在这篇综述中，我们总结了迄今为止在黑色素瘤中试验的各种化疗方案，并讨论了化疗在治疗黑色素瘤方面仍可能发挥的作用，可能与更新的药物联合使用，或在某些黑色素瘤亚型中发挥的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The role for chemotherapy in the modern management of melanoma.

The treatment of malignant melanoma has changed beyond recognition in the last 7 years. Where previously single agent dacarbazine was often the only treatment used for advanced disease, now there are potentially multiple lines of treatment, based on immunotherapy and targeted treatment options, either as monotherapy or in combination. In this brave new world the question arises, does chemotherapy still have any relevance in the modern management of melanoma? In this review, we summarize the various chemotherapeutic options that have been trialled in melanoma to date, and discuss the role chemotherapy may still play in treating melanoma, potentially in combination with more novel agents, or in certain subtypes of melanoma.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.