[Chemical Constituents of the Aerial Parts from Plumbago zeylanica].

Objective: To study the anti-oxidative constituents of the aerial parts of Plumbago zeylanica.

Methods: The ethanol extract of Plumbago zeylanica was separated and purified by various chromatographic techniques. On the basis of various spectroscopic data, the structures of isolated compounds were elucidated. ABTS+radical scavenging were carried out in antioxidant activity evaluation of the isolated compounds.

Results: Eleven compounds were isolated and identified as cis-isoshinanolone-4-O-β-D-glucopyranoside( 1),tachioside( 2),2,6-dimethoxy-p-hydroquinone-1-O-β-D-glucopyranoside( 3),3-( β-D-glucopyranosyloxy)-4-methoxybenzoic acid( 4),3’-O-β-D-glucopyranosyloxy-plumbagic acid( 5),3’-O-β-D-glucopyranosyloxy-plumbagic acid methyl ester( 6),plumbagic acid( 7),plumbagine A( 8),plumbagine C( 9),syringate-4-O-β-D-glucopyranoside( 10) and 2-methyl-5-hydroxychromone( 11). Compounds 2,3,and5 displayed significant scavenging effect on ABTS+.

Conclusion: Compounds 1 ~ 4,10,11 are obtained from this plant for the first time. Compounds 2,3,and 5 show significant anti-oxidative effects.