葛根改善胰岛素抵抗的网络药理研究

中药材 Pub Date : 2016-07-01

Wei-dong Lin, Jing-min Hu, Sheng-wang Liang, Shu-mei Wang, Yuan-xin Tian

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引用次数: 0

摘要

目的:应用网络药理学方法，探讨葛根改善胰岛素抵抗的有效成分及其作用机制。方法:基于分子对接技术选择与胰岛素抵抗相关的关键靶蛋白，将所选组分与4个通路的31个靶蛋白进行对接。同时，利用Cytoscape 3软件建立组分-靶蛋白网络进行网络分析。2. 1.结果:19个化合物与AMPK等4条通路有密切的相互作用。经文献验证的成分有13种，初步揭示了葛根改善胰岛素抵抗的有效成分及其潜在的分子机制。结论:网络药理学方法有助于探索葛根中可能的有效成分并阐明其作用机制。

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[Network Pharmacological Studies of Puerariae Radix in Improving Insulin Resistance].

Objective: To investigate the active components and potential mechanism of Puerariae Radix in improving insulin resistance by using network pharmacological method.

Methods: Key target proteins related with insulin resistance were selected based on molecular docking technology, and then took the selected components with 31 target proteins of four pathways for docking. Meanwhile, component-target proteins network was established to network analysis by software Cytoscape 3. 2. 1.

Results: 19 compounds had close interactions with four pathways such as AMPK. There were 13 compositions can verify through literature, which revealing that active ingredients and potential molecular mechanism of Puerariae Radix in improving insulin resistance, preliminarily.

Conclusion: The network pharmacological method is helpful to explore the possible active components in Puerariae Radix and elucidate the mechanism.

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来源期刊

中药材

自引率

0.00%

发文量

11364

期刊介绍： "Chinese Materia Medica" magazine was founded in 1978. It is a national-level academic journal of Chinese medicine science and technology approved by the State Science and Technology Commission and the Press and Publication Administration for public distribution at home and abroad. It is sponsored by the Chinese Materia Medica Information Center of the State Food and Drug Administration and is publicly distributed at home and abroad. It mainly reports on new technologies, new methods and new achievements in the production, scientific research and business management of Chinese medicine, and serves to promote the production and scientific and technological development of Chinese medicine, improve the output and quality of Chinese medicine, improve business management, and prosper the Chinese medicine industry.