川崎病冠状动脉瘤发生和持续的危险因素。

Korean Journal of Pediatrics Pub Date : 2019-04-01 Epub Date: 2018-11-22 DOI:10.3345/kjp.2018.07052
Soo-Kyeong Jeon, Geena Kim, Hoon Ko, Joung-Hee Byun, Hyoung Doo Lee
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引用次数: 6

摘要

目的:研究川崎病冠状动脉瘤的预后因素。本研究的目的是确定与川崎病治疗患者早期和晚期冠状动脉预后相关的危险因素。方法:回顾性选择2012年1月至2015年12月在釜山国立大学儿童医院诊断为川崎病的392例患者作为研究对象,随访1年,确定冠状动脉瘤的危险因素及冠状动脉瘤的持续性。结果:392例川崎病患者中,30例在发病后1个月内检出冠状动脉瘤。随访1年后,30例患者中有5例冠状动脉瘤持续存在。发热持续时间长(调整优势比[OR], 1.47;95%置信区间[CI], 1.06-2.02;P=0.018)和高血小板计数(调整OR, 1.00;95% ci, 1.00-1.01;P=0.009)是预测冠状动脉瘤早期发展的独立因素。初始冠状动脉严重程度(调整OR, 46.0;95% ci, 2.01-1047.80;P=0.016)和高白细胞计数(调整OR, 1.17;95% ci, 1.01-1.36;P=0.028)是影响晚期冠状动脉瘤持续存在的重要因素。但多因素分析未发现显著影响因素。结论:这些资料显示了我单位冠状动脉瘤的早期和晚期随访情况。冠状动脉瘤消失的机制及相关因素有待进一步研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Risk factors for the occurrence and persistence of coronary aneurysms in Kawasaki disease.

Purpose: Prognostic factors of coronary aneurysms in Kawasaki disease have been investigated in many studies. The aim of this study was to identify risk factors associated with early and late coronary artery outcomes in treated patients with Kawasaki disease.

Methods: A total of 392 patients diagnosed with Kawasaki disease from January 2012 to December 2015 in Pusan National University Children's Hospital were retrospectively selected as subjects of the present study to determine risk factors for coronary aneurysms and persistence of coronary aneurysms after a 1-year follow-up.

Results: Coronary aneurysms were detected in 30 of 392 patients within 1 month after the occurrence of Kawasaki disease. Coronary aneurysms persisted in 5 of 30 patients after a 1-year follow-up. A long duration of fever (adjusted odds ratio [OR], 1.47; 95% confidence interval [CI], 1.06-2.02; P=0.018) and high platelet count (adjusted OR, 1.00; 95% CI, 1.00-1.01; P=0.009) were found to be independent factors to predict the development of coronary aneurysms in the early phase. Initial coronary severity (adjusted OR, 46.0; 95% CI, 2.01-1047.80; P=0.016) and a high white blood cell count (adjusted OR, 1.17; 95% CI, 1.01-1.36; P=0.028) were found to be significant factors for the persistence of late coronary aneurysms in univariate analysis. However, no significant factors were found in multivariate analysis.

Conclusion: These data showed early and late follow-up of coronary aneurysms in our unit. Further studies are needed to determine the mechanisms involved in the disappearance of coronary aneurysms and related factors.

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审稿时长
12 weeks
期刊介绍: Korean J Pediatr covers clinical and research works relevant to all aspects of child healthcare. The journal aims to serve pediatricians through the prompt publication of significant advances in any field of pediatrics and to rapidly disseminate recently updated knowledge to the public. Additionally, it will initiate dynamic, international, academic discussions concerning the major topics related to pediatrics. Manuscripts are categorized as review articles, original articles, and case reports. Areas of specific interest include: Growth and development, Neonatology, Pediatric neurology, Pediatric nephrology, Pediatric endocrinology, Pediatric cardiology, Pediatric allergy, Pediatric pulmonology, Pediatric infectious diseases, Pediatric immunology, Pediatric hemato-oncology, Pediatric gastroenterology, Nutrition, Human genetics, Metabolic diseases, Adolescence medicine, General pediatrics.
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