迈向以多肽为基础的生物电子学:导电模拟毛的还原论设计。

Bioelectronics in medicine Pub Date : 2018-05-01 Epub Date: 2018-05-25 DOI:10.2217/bem-2018-0003
Tom Guterman, Ehud Gazit
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引用次数: 17

摘要

蛋白质和多肽具有可使与电反应组织相互作用的医疗设备受益的固有特性。然而,蛋白质材料通常是电绝缘的,因此不适合用作导电元件在电子医疗和其他生物接口设备中。细菌蛋白纳米纤维(被称为e-pili)的固有导电性的发现,可能会引发模拟还原论设计,从而为改进现有电子医疗设备的功能提供机会。在这篇特别报道中,我们回顾了有关电毛菌性质的关键方面,并介绍了正在进行的设计模拟导电纳米结构的努力。我们强调了使用自组装肽作为构建块的优势,并讨论了设想的模拟纳米结构的前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Toward peptide-based bioelectronics: reductionist design of conductive pili mimetics.

Proteins and peptides possess inherent properties which can benefit medical devices that interact with electro-responsive tissues. However, proteinaceous materials are typically electrically insulating and hence are not suitable to be utilized as conductive elements in electromedical and other bio-interfacing devices. The discovery of intrinsic electrical conductivity in bacterial protein nanofibers, termed e-pili, could give rise to mimetic reductionist design and thus provide an opportunity to improve the function of existing electromedical devices. In this Special Report we review key aspects concerning the properties of e-pili and present the ongoing effort toward the design of mimetic conductive nanostructures. We highlight the advantages of using self-assembling peptides as building blocks for this purpose and discuss the prospect of the envisioned mimetic nanostructures.

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