马来西亚 6-19 岁儿童和青少年发育迟缓的特征和相关因素。

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2019-03-04 eCollection Date: 2019-01-01 DOI:10.1017/gheg.2019.1
Uttara Partap, Elizabeth H Young, Pascale Allotey, Manjinder S Sandhu, Daniel D Reidpath
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引用次数: 0

摘要

背景:尽管有新的证据表明,发育迟缓在年龄较大时是可逆的,但大多数发育迟缓研究仍侧重于 5 岁以下儿童。我们的目的是评估发育迟缓的发生率,并研究马来西亚人口中年龄较大的儿童和青少年发育迟缓风险的社会人口分布情况:我们使用了居住在马来西亚昔加末的 6759 名 6-19 岁儿童和青少年的横截面数据。我们使用科恩系数(Cohen's κ coefficient)比较了根据美国疾病控制和预防中心(CDC)和世界卫生组织(WHO)参考标准定义的发育迟缓患病率估计值。使用带稳健标准误差的混合效应泊松回归检验了社会人口指数与发育迟缓风险之间的关联:两个参考文献对儿童和青少年身高发育迟缓或正常的分类差异很大(CDC 与 WHO;κ 一致度:0.73),但无论哪个参考文献,发育迟缓的患病率都很高(粗患病率:CDC:29.2%;WHO:19.1%)。体重不足儿童和青少年的发育迟缓风险比体重正常儿童和青少年高出约 19% (p = 0.030),比超重儿童和青少年低 21% (p = 0.001),并且随着家庭饮用水源的改善而大幅降低[自来水入户的风险比 (RR) 为 0.35,95% 置信区间 (95% CI) 为 0.30-0.41,p < 0.001]。卫生设施的改善也具有保护作用(抽水马桶的风险比:0.41,95% 置信区间为 0.19-0.88,p = 0.023)。在多重敏感性分析中,相关性未受到实质性影响:我们的研究结果为解决儿童发育迟缓问题的战略框架提供了依据,并强调有必要就大龄儿童和青少年发育迟缓的单一定义达成共识,以简化监测工作。
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Characterisation and correlates of stunting among Malaysian children and adolescents aged 6-19 years.

Background: Despite emerging evidence regarding the reversibility of stunting at older ages, most stunting research continues to focus on children below 5 years of age. We aimed to assess stunting prevalence and examine the sociodemographic distribution of stunting risk among older children and adolescents in a Malaysian population.

Methods: We used cross-sectional data on 6759 children and adolescents aged 6-19 years living in Segamat, Malaysia. We compared prevalence estimates for stunting defined using the Centers for Disease Control and Prevention (CDC) and the World Health Organization (WHO) references, using Cohen's κ coefficient. Associations between sociodemographic indices and stunting risk were examined using mixed-effects Poisson regression with robust standard errors.

Results: The classification of children and adolescents as stunted or normal height differed considerably between the two references (CDC v. WHO; κ for agreement: 0.73), but prevalence of stunting was high regardless of reference (crude prevalence: CDC 29.2%; WHO: 19.1%). Stunting risk was approximately 19% higher among underweight v. normal weight children and adolescents (p = 0.030) and 21% lower among overweight children and adolescents (p = 0.001), and decreased strongly with improved household drinking water sources [risk ratio (RR) for water piped into house: 0.35, 95% confidence interval (95% CI) 0.30-0.41, p < 0.001). Protective effects were also observed for improved sanitation facilities (RR for flush toilet: 0.41, 95% CI 0.19-0.88, p = 0.023). Associations were not materially affected in multiple sensitivity analyses.

Conclusions: Our findings justify a framework for strategies addressing stunting across childhood, and highlight the need for consensus on a single definition of stunting in older children and adolescents to streamline monitoring efforts.

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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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